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Mantosh Kumar Satapathy

Bio: Mantosh Kumar Satapathy is an academic researcher from Taipei Medical University. The author has contributed to research in topics: Self-healing hydrogels & Silver nanoparticle. The author has an hindex of 7, co-authored 15 publications receiving 606 citations. Previous affiliations of Mantosh Kumar Satapathy include National Institute of Technology, Durgapur.

Papers
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Journal ArticleDOI
TL;DR: In this article, an efficient and sustainable route of AgNP preparation from 1mM aqueous AgNO3 using leaf extracts of three plants, Musa balbisiana (banana), Azadirachta indica (neem) and Ocimum tenuiflorum (black tulsi), well adorned for their wide availability and medicinal property.
Abstract: In recent years, green synthesis of silver nanoparticles (AgNPs) has gained much interest from chemists and researchers. In this concern, Indian flora has yet to divulge innumerable sources of cost-effective non-hazardous reducing and stabilizing compounds utilized in preparing AgNPs. This study investigates an efficient and sustainable route of AgNP preparation from 1 mM aqueous AgNO3 using leaf extracts of three plants, Musa balbisiana (banana), Azadirachta indica (neem) and Ocimum tenuiflorum (black tulsi), well adorned for their wide availability and medicinal property. AgNPs were prepared by the reaction of 1 mM silver nitrate and 5% leaf extract of each type of plant separately. the AgNPs were duely characterized and tested for their antibacterial activity and toxicity. The AgNPs were characterized by UV-visible (vis) spectrophotometer, particle size analyzer (DLS), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and energy-dispersive spectroscopy (EDS). Fourier transform infrared spectrometer (FTIR) analysis was carried out to determine the nature of the capping agents in each of these leaf extracts. AgNPs obtained showed significantly higher antimicrobial activities against Escherichia coli (E. coli) and Bacillus sp. in comparison to both AgNO3 and raw plant extracts. Additionally, a toxicity evaluation of these AgNP containing solutions was carried out on seeds of Moong Bean (Vigna radiata) and Chickpea (Cicer arietinum). Results showed that seeds treated with AgNP solutions exhibited better rates of germination and oxidative stress enzyme activity nearing control levels, though detailed mechanism of uptake and translocation are yet to be analyzed. In totality, the AgNPs prepared are safe to be discharged in the environment and possibly utilized in processes of pollution remediation. AgNPs may also be efficiently utilized in agricultural research to obtain better health of crop plants as shown by our study.

506 citations

Journal ArticleDOI
TL;DR: In this article, a cost effective and environment friendly technique was developed for green synthesis of silver nanoparticles from silver nitrate solution through the leaf extract of Azadirachta indica as reducing as well as capping agent and was then used to synthesized soil-AgNP nanocomposite.
Abstract: This paper focused on the development and application of a novel method for preparation and characterization of soil coated with plant mediated synthesized AgNPs as a novel nanoadsorbent. A cost effective and environment friendly technique was developed for green synthesis of silver nanoparticles from silver nitrate solution through the leaf extract of Azadirachta indica as reducing as well as capping agent and was then used to synthesized soil–AgNP nanocomposite. Response surface methodology (RSM) was employed to investigate the effect of different operating parameters on the uptake of crystal violet (CV) using the novel nanocomposite materials A two level three factor (23) factorial central composite design (CCD) was used for the optimization of the process parameters and to evaluate the effects and interactions of process variables: initial solution pH (4.0–9.0), time requirement (30–90 min), and agitation speed (80–180 rpm) were studied. Multiple response optimization was applied to the experimental data to discover the optimal conditions for a set of response, simultaneously, by using a desirability function. The optimum removal efficiency of the Ag-nanocomposite adsorbent for CV adsorption was found as 99.995%.

83 citations

Journal ArticleDOI
TL;DR: In this paper, green synthesis of silver nanoparticles (AgNPs) having antibacterial efficacy, had been carried out using leaf extracts of Azadirachta indica as reducing as well as capping agent.
Abstract: Toxicity of textile effluent is a globally alarming issue nowadays In order to address this problem, a cost-effective and environment-friendly technique for adsorption of toxic dyes has been introduced in this research Firstly in this study, green synthesis of silver nanoparticles (AgNPs) having antibacterial efficacy, had been carried out using leaf extracts of Azadirachta indica as reducing as well as capping agent This research idea was further extended for the development and application of a novel method of preparation of silver-nanocomposite using synthesized microwave-assisted AgNPs with soil as a novel nanocomposite to adsorb hazardous dyes However, this nanocomposite was found to possess higher efficiency and adsorption capacity in comparison to soil as adsorbent for the removal of crystal violet dye under same experimental conditions Additionally, it was also observed that use of this Ag-nanocomposite as adsorbent helped in achieving about 972 % removal of crystal violet dye from the effluent solution

60 citations

Journal ArticleDOI
TL;DR: In this paper, solid lipid nanoparticles (SLNs) have been used as a putative drug carrier system that can deliver the active therapeutics (drugloaded SLNs) across the BBB at the target site of the brain, offering a novel approach with controlled drug delivery, longer circulation time, target specificity, and higher efficacy, and more importantly, reducing toxicity in a biomimetic way.
Abstract: The blood–brain barrier (BBB) plays a vital role in the protection and maintenance of homeostasis in the brain. In this way, it is an interesting target as an interface for various types of drug delivery, specifically in the context of the treatment of several neuropathological conditions where the therapeutic agents cannot cross the BBB. Drug toxicity and on-target specificity are among some of the limitations associated with current neurotherapeutics. In recent years, advances in nanodrug delivery have enabled the carrier system containing the active therapeutic drug to target the signaling pathways and pathophysiology that are closely linked to central nervous system (CNS) disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), multiple sclerosis (MS), brain tumor, epilepsy, ischemic stroke, and neurodegeneration. At present, among the nano formulations, solid lipid nanoparticles (SLNs) have emerged as a putative drug carrier system that can deliver the active therapeutics (drug-loaded SLNs) across the BBB at the target site of the brain, offering a novel approach with controlled drug delivery, longer circulation time, target specificity, and higher efficacy, and more importantly, reducing toxicity in a biomimetic way. This paper highlights the synthesis and application of SLNs as a novel nontoxic formulation strategy to carry CNS drugs across the BBB to improve the use of therapeutics agents in treating major neurological disorders in future clinics.

53 citations

Journal ArticleDOI
TL;DR: In this paper, a cationic photothermal triggerable/guidable gelatin hydrogel containing a polyethylenimine (PEI)-Ppy nanocomplex with a porous microstructure was established, and its physicochemical characteristics were studied through dynamic light scattering, scanning electronic microscopy, transmission electron microscopy and an FTIR; and cellular interaction behaviors towards fibroblasts incubated with a test sample were examined via MTT assay and fluorescence microscopy.
Abstract: The introduction and designing of functional thermoresponsive hydrogels have been recommended as recent potential therapeutic approaches for biomedical applications. The development of bioactive materials such as thermosensitive gelatin-incorporated nano-organic materials with a porous structure and photothermally triggerable and cell adhesion properties may potentially achieve this goal. This novel class of photothermal hydrogels can provide an advantage of hyperthermia together with a reversibly transformable hydrogel for tissue engineering. Polypyrrole (Ppy) is a bioorganic conducting polymeric substance and has long been used in biomedical applications owing to its brilliant stability, electrically conductive features, and excellent absorbance around the near-infrared (NIR) region. In this study, a cationic photothermal triggerable/guidable gelatin hydrogel containing a polyethylenimine (PEI)–Ppy nanocomplex with a porous microstructure was established, and its physicochemical characteristics were studied through dynamic light scattering, scanning electronic microscopy, transmission electron microscopy, an FTIR; and cellular interaction behaviors towards fibroblasts incubated with a test sample were examined via MTT assay and fluorescence microscopy. Photothermal performance was evaluated. Furthermore, the in vivo study was performed on male Wistar rat full thickness excisions model for checking the safety and efficacy of the designed gelatin–PEI–Ppy nanohydrogel system in wound healing and for other biomedical uses in future. This photothermally sensitive hydrogel system has an NIR-triggerable property that provides local hyperthermic temperature by PEI–Ppy nanoparticles for tissue engineering applications. Features of the designed hydrogel may fill other niches, such as being an antibacterial agent, generation of free radicals to further improve wound healing, and remodeling of the promising photothermal therapy for future tissue engineering applications.

47 citations


Cited by
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TL;DR: This review summarized the fundamental processes and mechanisms of “green” synthesis approaches, especially for metal and metal oxide nanoparticles using natural extracts and explored the role of biological components, essential phytochemicals (e.g., flavonoids, alkaloids, terpenoids, amides, and aldehydes) as reducing agents and solvent systems.
Abstract: In materials science, “green” synthesis has gained extensive attention as a reliable, sustainable, and eco-friendly protocol for synthesizing a wide range of materials/nanomaterials including metal/metal oxides nanomaterials, hybrid materials, and bioinspired materials. As such, green synthesis is regarded as an important tool to reduce the destructive effects associated with the traditional methods of synthesis for nanoparticles commonly utilized in laboratory and industry. In this review, we summarized the fundamental processes and mechanisms of “green” synthesis approaches, especially for metal and metal oxide [e.g., gold (Au), silver (Ag), copper oxide (CuO), and zinc oxide (ZnO)] nanoparticles using natural extracts. Importantly, we explored the role of biological components, essential phytochemicals (e.g., flavonoids, alkaloids, terpenoids, amides, and aldehydes) as reducing agents and solvent systems. The stability/toxicity of nanoparticles and the associated surface engineering techniques for achieving biocompatibility are also discussed. Finally, we covered applications of such synthesized products to environmental remediation in terms of antimicrobial activity, catalytic activity, removal of pollutants dyes, and heavy metal ion sensing.

1,175 citations

Journal ArticleDOI
Shakeel Ahmed1, Saifullah1, Mudasir Ahmad1, Babu Lal Swami1, Saiqa Ikram1 
TL;DR: In this article, a simple approach was applied for synthesis of silver nanoparticles using Azadirachta indica aqueous leaf extract, which acts both as reducing agent as well as cappi...

796 citations

Journal ArticleDOI
TL;DR: It has been demonstrated that Ag NPs arrest the growth and multiplication of many bacteria such as Bacillus cereus, Staphylococcus aureus, Citrobacter koseri, Salmonella typhii, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumonia, Vibrio parahaemolyticus and fungus.
Abstract: Use of silver and silver salts is as old as human civilization but the fabrication of silver nanoparticles (Ag NPs) has only recently been recognized. They have been specifically used in agriculture and medicine as antibacterial, antifungal and antioxidants. It has been demonstrated that Ag NPs arrest the growth and multiplication of many bacteria such as Bacillus cereus, Staphylococcus aureus, Citrobacter koseri, Salmonella typhii, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumonia, Vibrio parahaemolyticus and fungus Candida albicans by binding Ag/Ag+ with the biomolecules present in the microbial cells. It has been suggested that Ag NPs produce reactive oxygen species and free radicals which cause apoptosis leading to cell death preventing their replication. Since Ag NPs are smaller than the microorganisms, they diffuse into cell and rupture the cell wall which has been shown from SEM and TEM images of the suspension containing nanoparticles and pathogens. It has also been shown that smaller nanoparticles are more toxic than the bigger ones. Ag NPs are also used in packaging to prevent damage of food products by pathogens. The toxicity of Ag NPs is dependent on the size, concentration, pH of the medium and exposure time to pathogens.

766 citations

Journal ArticleDOI
TL;DR: This review describes the methods of green synthesis for Ag-NPs and their numerous applications and describes the comparison of efficient synthesis methods via green routes over physical and chemical methods, which provide strong evidence for the selection of suitable method for the synthesis of Ag-Ns.
Abstract: Development of reliable and eco-accommodating methods for the synthesis of nanoparticles is a vital step in the field of nanotechnology. Silver nanoparticles are important because of their exceptional chemical, physical, and biological properties, and hence applications. In the last decade, numerous efforts were made to develop green methods of synthesis to avoid the hazardous byproducts. This review describes the methods of green synthesis for Ag-NPs and their numerous applications. It also describes the comparison of efficient synthesis methods via green routes over physical and chemical methods, which provide strong evidence for the selection of suitable method for the synthesis of Ag-NPs.

502 citations

Journal ArticleDOI
TL;DR: Green chemistry was employed for the synthesis of silver nanoparticles (AgNPs) using leaf extracts of Ocimum Sanctum (Tulsi) and its derivative quercetin separately as precursors to investigate the role of biomolecules present in Tulsi in the formation of AgNPs from cationic silver under different physicochemical conditions.
Abstract: The rewards of using plants and plant metabolites over other biological methods for nanoparticle synthesis have fascinated researchers to investigate mechanisms of metal ions uptake and bio-reduction by plants. Here, green chemistry were employed for the synthesis of silver nanoparticles (AgNPs) using leaf extracts of Ocimum Sanctum (Tulsi) and its derivative quercetin (flavonoid present in Tulsi) separately as precursors to investigate the role of biomolecules present in Tulsi in the formation of AgNPs from cationic silver under different physicochemical conditions such as pH, temperature, reaction time and reactants concentration. The size, shape, morphology, and stability of resultant AgNPs were investigated by optical spectroscopy (absorption, photoluminescence (PL), PL-lifetime and Fourier transform infrared), X-ray diffraction (XRD) analysis, and transmission electron microscopy (TEM). The enhanced antibacterial activity of AgNPs against E-Coli gram-negative bacterial strains was analyzed based on the zone of inhibition and minimal inhibitory concentration (MIC) indices. The results of different characterization techniques showed that AgNPs synthesized using both leaf extract and neat quercetin separately followed the same optical, morphological, and antibacterial characteristics, demonstrating that biomolecules (quercetin) present in Tulsi are mainly responsible for the reduction of metal ions to metal nanoparticles.

456 citations