Manuel Boix-Chornet

TL;DR: Older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait, indicating how an appreciation of epigenetics is missing from the understanding of how different phenotypes can be originated from the same genotype.

TL;DR: It is found that cancer cells had a loss of monoacetylated and trimethylated forms of histone H4 early and accumulated during the tumorigenic process, which is a common hallmark of human tumor cells.

TL;DR: The identified truncating mutations in one of the primary human histone deacetylases, HDAC2, are identified in sporadic carcinomas with microsatellite instability and in tumors arising in individuals with hereditary nonpolyposis colorectal cancer syndrome and support the use ofHDAC2 mutational status in future pharmacogenetic treatment of these individuals.

TL;DR: It is demonstrated that relative to normal myeloid stem/progenitor cells, RARalpha2 expression is dramatically reduced in primary AML blasts and the notion that diminished RARA expression contributes to leukemogenesis is supported.

TL;DR: It is demonstrated that the cellular activities of Aiolos isoforms are dependent on combinations of various functional domains arising from the differential splicing of mRNA transcripts, and these data support the general principle that the function of an individual protein is modulated through alternative splicing.