M
Manuel Mayr
Researcher at King's College London
Publications - 350
Citations - 23602
Manuel Mayr is an academic researcher from King's College London. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 77, co-authored 313 publications receiving 19487 citations. Previous affiliations of Manuel Mayr include St George's, University of London & The Royal Marsden NHS Foundation Trust.
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Journal ArticleDOI
Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes
Anna Zampetaki,Stefan Kiechl,Ignat Drozdov,Peter Willeit,Ursula Mayr,Marianna Prokopi,Agnes Mayr,Siegfried Weger,Friedrich Oberhollenzer,Enzo Bonora,Ajay M. Shah,Johann Willeit,Manuel Mayr +12 more
TL;DR: A plasma miRNA signature for DM is revealed that includes loss of endothelial miR-126, which might explain the impaired peripheral angiogenic signaling in patients with DM.
Journal ArticleDOI
Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs.
Eduard Hergenreider,Susanne Heydt,Karine Tréguer,Thomas Boettger,Anton J.G. Horrevoets,Andreas M. Zeiher,Margot P. Scheffer,Achilleas S. Frangakis,Xiaoke Yin,Manuel Mayr,Thomas Braun,Carmen Urbich,Reinier A. Boon,Stefanie Dimmeler +13 more
TL;DR: The results show that atheroprotective stimuli induce communication between endothelial cells and SMCs through an miRNA- and extracellular-vesicle-mediated mechanism and that this may comprise a promising strategy to combat atherosclerosis.
Journal ArticleDOI
Cardiac fibroblast–derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy
Claudia Bang,Sandor Batkai,Seema Dangwal,Shashi Kumar Gupta,Ariana Foinquinos,Angelika Holzmann,Annette Just,Janet Remke,Karina Zimmer,Andre Zeug,Evgeni Ponimaskin,Andreas Schmiedl,Xiaoke Yin,Manuel Mayr,Rashi Halder,Andre Fischer,Stefan Engelhardt,Yuanyuan Wei,Andreas Schober,Jan Fiedler,Thomas Thum +20 more
TL;DR: It is found that cardiac fibroblasts secrete star miRNA-enriched exosomes and fibroblast-derived miR-21* is identified as a paracrine signaling mediator of cardiomyocyte hypertrophy that has potential as a therapeutic target.
Journal ArticleDOI
Cardioprotection and lifespan extension by the natural polyamine spermidine
Tobias Eisenberg,Mahmoud Abdellatif,Sabrina Schroeder,Uwe Primessnig,Uwe Primessnig,Slaven Stekovic,Tobias Pendl,Alexandra Harger,Alexandra Harger,Julia Schipke,Andreas Zimmermann,Albrecht Schmidt,Mingming Tong,Christoph Ruckenstuhl,Christopher Dammbrueck,Angelina S. Gross,Viktoria Herbst,Christoph Magnes,Gert Trausinger,Sophie H. Narath,Andreas Meinitzer,Zehan Hu,Zehan Hu,Alexander H. Kirsch,Kathrin Eller,Didac Carmona-Gutierrez,Sabrina Büttner,Sabrina Büttner,Federico Pietrocola,Oskar Knittelfelder,Emilie Schrepfer,Patrick Rockenfeller,Patrick Rockenfeller,Corinna Simonini,Alexandros Rahn,Marion Horsch,Kristin Moreth,Johannes Beckers,Helmut Fuchs,Valerie Gailus-Durner,Frauke Neff,Dirk Janik,Birgit Rathkolb,Jan Rozman,Martin Hrabé de Angelis,Tarek Moustafa,Tarek Moustafa,Guenter Haemmerle,Manuel Mayr,Peter Willeit,Peter Willeit,Marion von Frieling-Salewsky,Burkert Pieske,Burkert Pieske,Luca Scorrano,Thomas R. Pieber,Thomas R. Pieber,Raimund Pechlaner,Johann Willeit,Stephan J. Sigrist,Stephan J. Sigrist,Wolfgang A. Linke,Christian Mühlfeld,Junichi Sadoshima,Joern Dengjel,Joern Dengjel,Stefan Kiechl,Guido Kroemer,Simon Sedej,Frank Madeo +69 more
TL;DR: It is shown that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice, and suggests a new and feasible strategy for protection against cardiovascular disease.
Journal ArticleDOI
Chronic Infections and the Risk of Carotid Atherosclerosis Prospective Results From a Large Population Study
Stefan Kiechl,Georg Egger,Manuel Mayr,Christian J. Wiedermann,Enzo Bonora,Friedrich Oberhollenzer,Michele Muggeo,Qingbo Xu,Georg Wick,Werner Poewe,Johann Willeit +10 more
TL;DR: Chronic infections amplified the risk of atherosclerosis development in the carotid arteries and remained independently significant after adjustment for classic vascular risk attribu...