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Manuela Antonioli

Researcher at University of Rome Tor Vergata

Publications -  31
Citations -  7921

Manuela Antonioli is an academic researcher from University of Rome Tor Vergata. The author has contributed to research in topics: Autophagy & Autophagy-Related Protein-1 Homolog. The author has an hindex of 20, co-authored 29 publications receiving 6918 citations. Previous affiliations of Manuela Antonioli include University of Freiburg.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

Francesca Nazio, +10 more
- 01 Apr 2013 - 
TL;DR: As ULK1 has been shown to activate AMBRA1 by phosphorylation, the proposed pathway may act as a positive regulation loop, which may be targeted in human disorders linked to impaired autophagy.
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The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

Sabrina Di Bartolomeo, +15 more
- 04 Oct 2010 - 
TL;DR: When autophagy is induced, ULK1 phosphorylates AMBRA1, releasing the autophagic core complex from the cytoskeleton and allowing its relocalization to the ER membrane to nucleate autophagosome formation.
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AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

Valentina Cianfanelli, +21 more
- 01 Jan 2015 - 
TL;DR: It is shown that the scaffold protein AMBRA1 regulates cell proliferation by facilitating the dephosphorylation and degradation of the proto-oncogene c-Myc and that, when mTOR is inhibited, it enhances PP2A activity on this specific target, thereby reducing the cell division rate.
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Emerging Mechanisms in Initiating and Terminating Autophagy

Manuela Antonioli, +3 more
- 01 Jan 2017 - 
TL;DR: How stress signaling pathways dynamically control the activity of the autophagy machinery by mediating post-translational modifications and regulatory protein interactions is discussed.