抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

“Unpaired Image-to-Image Translation using Cycle-Consistent Adversarial Networks”の学習報告

Social Network Analysis

The organization of behavior: A neuropsychological theory

https://bura.brunel.ac.uk/bitstream/2438/14221/1/FullText.pdf

A survey of deep neural network architectures and their applications

In this paper, we present an improved fuzzy C-means (FCM) algorithm for image segmentation by introducing a tradeoff weighted fuzzy factor and a kernel metric. The tradeoff weighted fuzzy factor depends on the space distance of all neighboring pixels and their gray-level difference simultaneously. By using this factor, the new algorithm can accurately estimate the damping extent of neighboring pixels. In order to further enhance its robustness to noise and outliers, we introduce a kernel distance measure to its objective function. The new algorithm adaptively determines the kernel parameter by using a fast bandwidth selection rule based on the distance variance of all data points in the collection. Furthermore, the tradeoff weighted fuzzy factor and the kernel distance measure are both parameter free. Experimental results on synthetic and real images show that the new algorithm is effective and efficient, and is relatively independent of this type of noise.

Fuzzy C-Means Clustering With Local Information and Kernel Metric for Image Segmentation

This paper presents a novel change detection approach for synthetic aperture radar images based on deep learning. The approach accomplishes the detection of the changed and unchanged areas by designing a deep neural network. The main guideline is to produce a change detection map directly from two images with the trained deep neural network. The method can omit the process of generating a difference image (DI) that shows difference degrees between multitemporal synthetic aperture radar images. Thus, it can avoid the effect of the DI on the change detection results. The learning algorithm for deep architectures includes unsupervised feature learning and supervised fine-tuning to complete classification. The unsupervised feature learning aims at learning the representation of the relationships between the two images. In addition, the supervised fine-tuning aims at learning the concepts of the changed and unchanged pixels. Experiments on real data sets and theoretical analysis indicate the advantages, feasibility, and potential of the proposed method. Moreover, based on the results achieved by various traditional algorithms, respectively, deep learning can further improve the detection performance.

Change Detection in Synthetic Aperture Radar Images Based on Deep Neural Networks

This paper presents an unsupervised distribution-free change detection approach for synthetic aperture radar (SAR) images based on an image fusion strategy and a novel fuzzy clustering algorithm. The image fusion technique is introduced to generate a difference image by using complementary information from a mean-ratio image and a log-ratio image. In order to restrain the background information and enhance the information of changed regions in the fused difference image, wavelet fusion rules based on an average operator and minimum local area energy are chosen to fuse the wavelet coefficients for a low-frequency band and a high-frequency band, respectively. A reformulated fuzzy local-information C-means clustering algorithm is proposed for classifying changed and unchanged regions in the fused difference image. It incorporates the information about spatial context in a novel fuzzy way for the purpose of enhancing the changed information and of reducing the effect of speckle noise. Experiments on real SAR images show that the image fusion strategy integrates the advantages of the log-ratio operator and the mean-ratio operator and gains a better performance. The change detection results obtained by the improved fuzzy clustering algorithm exhibited lower error than its preexistences.

Change Detection in Synthetic Aperture Radar Images based on Image Fusion and Fuzzy Clustering

Nondominated Neighbor Immune Algorithm (NNIA) is proposed for multiobjective optimization by using a novel nondominated neighbor-based selection technique, an immune inspired operator, two heuristic search operators, and elitism. The unique selection technique of NNIA only selects minority isolated nondominated individuals in the population. The selected individuals are then cloned proportionally to their crowding-distance values before heuristic search. By using the nondominated neighbor-based selection and proportional cloning, NNIA pays more attention to the less-crowded regions of the current trade-off front. We compare NNIA with NSGA-II, SPEA2, PESA-II, and MISA in solving five DTLZ problems, five ZDT problems, and three low-dimensional problems. The statistical analysis based on three performance metrics including the coverage of two sets, the convergence metric, and the spacing, show that the unique selection method is effective, and NNIA is an effective algorithm for solving multiobjective optimization problems. The empirical study on NNIA's scalability with respect to the number of objectives shows that the new algorithm scales well along the number of objectives.

/pdf/multiobjective-immune-algorithm-with-nondominated-neighbor-3m342iujs2.pdf

Multiobjective immune algorithm with nondominated neighbor-based selection

We propose an unsupervised deep convolutional coupling network for change detection based on two heterogeneous images acquired by optical sensors and radars on different dates. Most existing change detection methods are based on homogeneous images. Due to the complementary properties of optical and radar sensors, there is an increasing interest in change detection based on heterogeneous images. The proposed network is symmetric with each side consisting of one convolutional layer and several coupling layers. The two input images connected with the two sides of the network, respectively, are transformed into a feature space where their feature representations become more consistent. In this feature space, the different map is calculated, which then leads to the ultimate detection map by applying a thresholding algorithm. The network parameters are learned by optimizing a coupling function. The learning process is unsupervised, which is different from most existing change detection methods based on heterogeneous images. Experimental results on both homogenous and heterogeneous images demonstrate the promising performance of the proposed network compared with several existing approaches.

Maoguo Gong

Papers

Fuzzy C-Means Clustering With Local Information and Kernel Metric for Image Segmentation

Change Detection in Synthetic Aperture Radar Images Based on Deep Neural Networks

Change Detection in Synthetic Aperture Radar Images based on Image Fusion and Fuzzy Clustering

Multiobjective immune algorithm with nondominated neighbor-based selection

A Deep Convolutional Coupling Network for Change Detection Based on Heterogeneous Optical and Radar Images