M
Marc A. Pfeffer
Researcher at Brigham and Women's Hospital
Publications - 815
Citations - 143710
Marc A. Pfeffer is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Heart failure & Myocardial infarction. The author has an hindex of 166, co-authored 765 publications receiving 133043 citations. Previous affiliations of Marc A. Pfeffer include Partners HealthCare & University of Miami.
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Journal ArticleDOI
Renal function estimation and Cockroft-Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart 'OMics' in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives.
João Pedro Ferreira,Nicolas Girerd,Pierpaolo Pellicori,Kevin Duarte,Kevin Duarte,Kevin Duarte,Sophie Girerd,Marc A. Pfeffer,John J.V. McMurray,Bertram Pitt,Bertram Pitt,Kenneth Dickstein,Lotte Jacobs,Jan A. Staessen,Javed Butler,Roberto Latini,Serge Masson,Alexandre Mebazaa,Hans-Peter Brunner-La Rocca,Christian Delles,Stephane Heymans,Naveed Sattar,J. Wouter Jukema,John G.F. Cleland,Faiez Zannad,Patrick Rossignol,Patrick Rossignol +26 more
TL;DR: The CG-BSA formula was slightly more accurate in predicting CVM in CV risk, HF, and post-MI cohorts (but not in population-based cohorts), but the CKD-EPI formula was superior overall to MDRD4 and the latter offering the best compromise between renal function estimation and CVM prediction.
Journal ArticleDOI
Incident Hyperkalemia, Hypokalemia, and Clinical Outcomes During Spironolactone Treatment of Heart Failure With Preserved Ejection Fraction: Analysis of the TOPCAT Trial
Akshay S. Desai,Jiankang Liu,Marc A. Pfeffer,Brian Claggett,Jerome L. Fleg,Eldrin F. Lewis,Sonja M. McKinlay,Eileen O'Meara,Sanjiv J. Shah,Nancy K. Sweitzer,Scott D. Solomon,Bertram Pitt +11 more
TL;DR: Both hyperkalemia and hypokalemia are associated with heightened risk for mortality in HF-PEF and use of spironolactone in this population requires careful laboratory surveillance of K+ and creatinine, particularly in high-risk groups.
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Cardiac hypertrophy and performance of Dahl hypertensive rats on graded salt diets.
TL;DR: In young adult S rats, cardiac performance was well compensated since pump and contractile functions were maintained and pressure-generating capacity was increased in relation to the degree of LV hypertrophy.
Journal ArticleDOI
Improvements in clinical outcomes with the use of angiotensin-converting enzyme inhibitors: cross-fertilization between clinical and basic investigation.
TL;DR: Although developed as an antihypertensive agent, these effective interchanges have collectively produced convincing data to demonstrate that ACE inhibitors can and should be used to slow progression of renal disease, prevent and treat heart failure, attenuate adverse left ventricular remodeling after myocardial infarction and improve prognosis.
Journal ArticleDOI
Association Between ADAMTS1 Matrix Metalloproteinase Gene Variation, Coronary Heart Disease, and Benefit of Statin Therapy
Marc S. Sabatine,Lynn Marie Ploughman,Katy L. Simonsen,Olga Iakoubova,Todd G. Kirchgessner,Koustubh Ranade,Zenta Tsuchihashi,Kim E. Zerba,Diane U. Long,Carmen H. Tong,Christopher J. Packard,Marc A. Pfeffer,James J. Devlin,James Shepherd,Hannia Campos,Frank M. Sacks,Eugene Braunwald +16 more
TL;DR: In men not on pravastatin, those homozygous for the 227Pro allele of ADAMTS1 have a nearly 2-fold increased risk of coronary heart disease events compared with noncarriers.