M
Marc Bracke
Researcher at Ghent University Hospital
Publications - 9
Citations - 135
Marc Bracke is an academic researcher from Ghent University Hospital. The author has contributed to research in topics: Organ culture & Cancer cell. The author has an hindex of 7, co-authored 9 publications receiving 131 citations. Previous affiliations of Marc Bracke include Ghent University.
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Anti-invasive compounds
TL;DR: In this paper, a method for predicting the anti-invasive activity of chalcone-like compounds was proposed. But this method is not suitable for the use in the prevention and/or treatment of diseases associated with undesired cell invasion.
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Design, synthesis and structure-activity relationships of some novel, highly potent anti-invasive (E)- and (Z)-stilbenes.
Bart Roman,Laurens M. De Coen,Séverine Thérèse F.C. Mortier,Tine De Ryck,Barbara Vanhoecke,Alan R. Katritzky,Alan R. Katritzky,Marc Bracke,Christian V. Stevens +8 more
TL;DR: A number of structurally related (E)- and (Z)-stilbenes exhibited an extraordinary high in vitro potency in the chick heart invasion assay, being active up to 10nmolL(-1), a concentration level a 100-fold lower than the lowest effective doses that have been reported for natural analogues.
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Exploration of the SAR of anti-invasive chalcones: synthesis and biological evaluation of conformationally restricted analogues.
Bart Roman,Tine De Ryck,Laura Dierickx,Barbara Vanhoecke,Alan R. Katritzky,Alan R. Katritzky,Marc Bracke,Christian V. Stevens +7 more
TL;DR: In vitro anti-invasive activity data point towards an active conformation for chalcones more resembling their s-trans geometry than the s-cis counterpart.
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Further studies on anti-invasive chemotypes: An excursion from chalcones to curcuminoids.
TL;DR: In the 1,3-diarylpenta-2,4-dien-1-one series, fluoro and/or trimethoxy substitution caused an increase in potency, which agrees with observations made earlier for the chalcone class.
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Assessment of the Antineoplastic Potential of Chalcones in Animal Models
TL;DR: This review provides a comprehensive overview of the numerous in vivo animal studies on the antineoplastic potential of both natural and synthetic members of this flavonoid subclass (covering: up to mid-2011).