M
Marc Devocelle
Researcher at Royal College of Surgeons in Ireland
Publications - 106
Citations - 2399
Marc Devocelle is an academic researcher from Royal College of Surgeons in Ireland. The author has contributed to research in topics: Peptide & Antimicrobial peptides. The author has an hindex of 26, co-authored 100 publications receiving 2142 citations. Previous affiliations of Marc Devocelle include University College Dublin & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Regulation of Glucose Transporter 3 Surface Expression by the AMP-Activated Protein Kinase Mediates Tolerance to Glutamate Excitation in Neurons
TL;DR: The data suggest that the activation of AMPK and its regulation of cell surface GLUT3 expression is critical in mediating neuronal tolerance to excitotoxicity.
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AMP kinase–mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis
Caoimhín G. Concannon,Liam P. Tuffy,Petronela Weisová,Helena P. Bonner,David Dávila,Caroline Bonner,Marc Devocelle,Andreas Strasser,Manus W. Ward,Jochen H. M. Prehn +9 more
TL;DR: Disturbances in cellular ion gradients by excitotoxicity promote apoptosis through activation of the Bcl-2 family member Bim.
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Ruthenium polypyridyl peptide conjugates: membrane permeable probes for cellular imaging
Ute Neugebauer,Yann Pellegrin,Marc Devocelle,Robert J. Forster,William Signac,Niamh Moran,Tia E. Keyes +6 more
TL;DR: Two novel polyarginine labelled ruthenium polypyridyl dyes are reported, one conjugated to five, and one to eight arginine residues, (Ru-Ahx-R8); both complexes exhibit long-lived, intense, and oxygen-sensitive luminescence.
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A peptide corresponding to the neuropilin-1-binding site on VEGF(165) induces apoptosis of neuropilin-1-expressing breast tumour cells.
Martin P. Barr,Anne-Marie Byrne,Angela Duffy,Claire Condron,Marc Devocelle,Patrick Harriott,Patrick Harriott,David Bouchier-Hayes,Judith H. Harmey +8 more
TL;DR: It is demonstrated that NP-1 plays an essential role in autocrine antiapoptotic signalling by VEGF in tumour cells and that NP1-blockade induces tumour cell and endothelial cell apoptosis.
Journal ArticleDOI
Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8
Maike A. Laussmann,Egle Passante,Heiko Düssmann,Judith A. Rauen,Maximilian L. Würstle,Maria Eugenia Delgado,Marc Devocelle,Jochen H. M. Prehn,Markus Rehm +8 more
TL;DR: Combination treatments of proteasome inhibitors and XIAP antagonists therefore represent a promising strategy to eliminate highly resistant cancer cells, which overexpress antiapoptotic Bcl-2 family members.