M
Marc Naven
Researcher at Cardiff University
Publications - 5
Citations - 85
Marc Naven is an academic researcher from Cardiff University. The author has contributed to research in topics: Wnt signaling pathway & Chondrogenesis. The author has an hindex of 2, co-authored 3 publications receiving 62 citations.
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Journal ArticleDOI
Exome Resequencing Identifies Potential Tumor-Suppressor Genes that Predispose to Colorectal Cancer
Christopher Smith,Marc Naven,Rebecca Harris,James Colley,Hannah West,Ning Li,Yuan Liu,Richard Adams,Tim Maughan,Laura L Nichols,Richard Kaplan,Michael J. Wagner,Howard L. McLeod,Jeremy Peter Cheadle +13 more
TL;DR: Novel tumor‐suppressor genes that predispose to CRC are sought by exome resequencing 50 sporadic patients with advanced CRC at a mean coverage of 30×, and somatic mutations in the corresponding genes in the CRCs of the patients harboring the germline lesions are found.
Journal ArticleDOI
3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors.
Luned Badder,Andrew John Hollins,Bram Herpers,Kuan Yan,Kenneth Burnside Ramsay Ewan,Mairian Thomas,Jennifer R. Shone,Delyth A. Badder,Marc Naven,Kevin E. Ashelford,Rachel Hargest,Rachel Hargest,Alan Richard Clarke,Christina Esdar,Hans-Peter Buchstaller,J. Mark Treherne,Sylvia F. Boj,Bahar Ramezanpour,Dirk Wienke,Leo S. Price,Paul Shaw,Trevor Clive Dale +21 more
TL;DR: It is demonstrated that morphometric analyses can capture subtle alterations in organoid responses to Wnt inhibitors that are consistent with activity against a cancer stem cell subpopulation, highlighting the value of phenotypic readouts as a quantitative method to asses drug-induced effects in a relevant preclinical model.
Posted ContentDOI
3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors
Luned Badder,Andrew John Hollins,Bram Herpers,Kuan Yan,Kenneth Burnside Ramsay Ewan,Jennifer R. Shone,Delyth A. Badder,Marc Naven,Kevin E. Ashelford,Rachel Hargest,Rachel Hargest,Alan Richard Clarke,Christina Esdar,Hans-Peter Buchstaller,Dirk Wienke,Leo S. Price,Paul Shaw,Trevor Clive Dale +17 more
TL;DR: It is demonstrated that morphometric analyses can capture subtle alterations in organoid responses to Wnt inhibitors that are consistent with activity against a cancer stem cell subpopulation, highlighting the value of phenotypic readouts as a quantitative method to asses drug-induced effects in a relevant preclinical model.
Journal ArticleDOI
Development of human cartilage circadian rhythm in a stem cell-chondrogenesis model
Marc Naven,Leo A. H. Zeef,Shiyang Li,Paul A. Humphreys,Christopher A. Smith,Dharshika Pathiranage,Stuart A. Cain,Steven Paul Woods,Nicola Bates,Manting Au,Chunyi Wen,Susan J. Kimber,Qing-Jun Meng +12 more
TL;DR: The circadian clock is gradually activated through a differentiation-coupled mechanism in a human chondrogenesis model to investigate the role of the circadian clock during normal homeostasis and in diseases such as osteoarthritis.
Journal ArticleDOI
Directed differentiation of hPSCs through a simplified lateral plate mesoderm protocol for generation of articular cartilage progenitors
Christopher A. Smith,Paul A. Humphreys,Marc Naven,Steven Paul Woods,F. Mancini,Julieta O’Flaherty,Qing-Jun Meng,Susan J. Kimber +7 more
TL;DR: In this paper , a chondrogenic protocol was developed to produce a LP-osteochondral progenitor from which prechondrocyte-and preosteoblast-like cells can be generated.