M
Marc Prentki
Researcher at Université de Montréal
Publications - 193
Citations - 26660
Marc Prentki is an academic researcher from Université de Montréal. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 82, co-authored 186 publications receiving 24740 citations. Previous affiliations of Marc Prentki include University of Pennsylvania & University of Geneva.
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Journal ArticleDOI
A genome-wide association study identifies novel risk loci for type 2 diabetes
Robert Sladek,Ghislain Rocheleau,Johan Rung,Christian Dina,Lishuang Shen,David Serre,Philippe Boutin,Daniel Vincent,Alexandre Belisle,Samy Hadjadj,Beverley Balkau,Barbara Heude,Guillaume Charpentier,Thomas J. Hudson,Thomas J. Hudson,Alexandre Montpetit,Alexey V. Pshezhetsky,Marc Prentki,Barry I. Posner,David J. Balding,David Meyre,Constantin Polychronakos,Philippe Froguel,Philippe Froguel +23 more
TL;DR: Four loci containing variants that confer type 2 diabetes risk are identified and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits.
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Islet β cell failure in type 2 diabetes
TL;DR: The major focus of this Review is on the mechanisms of islet beta cell failure in the pathogenesis of obesity-associated type 2 diabetes (T2D).
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Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.
Hans E. Hohmeier,Hindrik Mulder,Guoxun Chen,Rosemarie Henkel-Rieger,Marc Prentki,Christopher B. Newgard +5 more
TL;DR: It is concluded that clonal selection of INS-1 cells allows isolation of cell lines that exhibit markedly enhanced and stable responsiveness to glucose and several of its known potentiators, which may be attractive new vehicles for studies of beta-cell function.
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Type 2 diabetes across generations: from pathophysiology to prevention and management
TL;DR: Evidence is emerging that a substantial part of diabetes susceptibility is acquired early in life, probably owing to fetal or neonatal programming via epigenetic phenomena, and maternal and early childhood health might, therefore, be crucial to the development of effective prevention strategies.