M
Marc R. Birtwistle
Researcher at Clemson University
Publications - 100
Citations - 3564
Marc R. Birtwistle is an academic researcher from Clemson University. The author has contributed to research in topics: Biology & MAPK/ERK pathway. The author has an hindex of 24, co-authored 82 publications receiving 2905 citations. Previous affiliations of Marc R. Birtwistle include Icahn School of Medicine at Mount Sinai & University of Delaware.
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Journal ArticleDOI
Raf Family Kinases: Old Dogs Have Learned New Tricks
David Matallanas,Marc R. Birtwistle,David Romano,Armin Zebisch,Jens Rauch,Alex von Kriegsheim,Walter Kolch +6 more
TL;DR: The regulation of Raf proteins and their role in cancer are discussed, with special focus on the interacting proteins that modulate Raf signaling, and new kinase-independent roles for Raf proteins have emerged.
Journal ArticleDOI
The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations
Alexandra B Keenan,Sherry L. Jenkins,Kathleen M. Jagodnik,Simon Koplev,Edward He,Denis Torre,Zichen Wang,Anders B. Dohlman,Moshe C. Silverstein,Alexander Lachmann,Maxim V. Kuleshov,Avi Ma'ayan,Vasileios Stathias,Raymond Terryn,Daniel J. Cooper,Michele Forlin,Amar Koleti,Dusica Vidovic,Caty Chung,Stephan C. Schürer,Jouzas Vasiliauskas,Marcin Pilarczyk,Behrouz Shamsaei,Mehdi Fazel,Yan Ren,Wen Niu,Nicholas A. Clark,Shana White,Naim Al Mahi,Lixia Zhang,Michal Kouril,John F. Reichard,Siva Sivaganesan,Mario Medvedovic,Jaroslaw Meller,Rick J. Koch,Marc R. Birtwistle,Ravi Iyengar,Eric A. Sobie,Evren U. Azeloglu,Julia A. Kaye,Jeannette Osterloh,Kelly Haston,Jaslin Kalra,Steve Finkbiener,Jonathan Z. Li,Pamela Milani,Miriam Adam,Renan Escalante-Chong,Karen Sachs,Alexander LeNail,Divya Ramamoorthy,Ernest Fraenkel,Gavin Daigle,Uzma Hussain,Alyssa Coye,Jeffrey D. Rothstein,Dhruv Sareen,Loren Ornelas,Maria G. Banuelos,Berhan Mandefro,Ritchie Ho,Clive N. Svendsen,Ryan G. Lim,Jennifer Stocksdale,Malcolm Casale,Terri G. Thompson,Jie Wu,Leslie M. Thompson,Victoria Dardov,Vidya Venkatraman,Andrea Matlock,Jennifer E. Van Eyk,Jacob D. Jaffe,Malvina Papanastasiou,Aravind Subramanian,Todd R. Golub,Sean D. Erickson,Mohammad Fallahi-Sichani,Marc Hafner,Nathanael S. Gray,Jia-Ren Lin,Caitlin E. Mills,Jeremy L. Muhlich,Mario Niepel,Caroline E. Shamu,Elizabeth H. Williams,David Wrobel,Peter K. Sorger,Laura M. Heiser,Joe W. Gray,James E. Korkola,Gordon B. Mills,Mark A. LaBarge,Mark A. LaBarge,Heidi S. Feiler,Mark A. Dane,Elmar Bucher,Michel Nederlof,Damir Sudar,Sean M. Gross,David Kilburn,Rebecca Smith,Kaylyn Devlin,Ron Margolis,Leslie Derr,Albert Lee,Ajay Pillai +107 more
TL;DR: The LINCS program focuses on cellular physiology shared among tissues and cell types relevant to an array of diseases, including cancer, heart disease, and neurodegenerative disorders.
Journal ArticleDOI
Cell fate decisions are specified by the dynamic ERK interactome
Alex von Kriegsheim,Daniela Baiocchi,Marc R. Birtwistle,David Sumpton,Willy V. Bienvenut,Nicholas A. Morrice,Kayo Yamada,Angus I. Lamond,Gabriella Kalna,Richard J. Orton,David Gilbert,David Gilbert,Walter Kolch,Walter Kolch +13 more
TL;DR: Assessing dynamic changes in ERK-interacting proteins that specifically occur under differentiation conditions confirmed that ERK dynamics and differentiation are regulated by distributed control mechanisms rather than by a single master switch.
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Ligand‐dependent responses of the ErbB signaling network: experimental and modeling analyses
Marc R. Birtwistle,Marc R. Birtwistle,Mariko Hatakeyama,Noriko Yumoto,Babatunde A. Ogunnaike,Jan B. Hoek,Boris N. Kholodenko +6 more
TL;DR: This work combines traditional experiments with computational modeling, building a model that describes how stimulation of all four ErbB receptors with epidermal growth factor and heregulin leads to activation of two critical downstream proteins, extracellular‐signal‐regulated kinase (ERK) and Akt.
Journal ArticleDOI
The Mammalian MAPK/ERK Pathway Exhibits Properties of a Negative Feedback Amplifier
Oliver E. Sturm,Richard J. Orton,Joan Grindlay,Marc R. Birtwistle,Vladislav Vyshemirsky,David Gilbert,Muffy Calder,Andrew R. Pitt,Boris N. Kholodenko,Walter Kolch +9 more
TL;DR: It is shown that the three-tiered kinase amplifier module combined with negative feedback recapitulates the design principles of a negative feedback amplifier (NFA), which is used in electronic circuits to confer robustness, output stabilization, and linearization of nonlinear signal amplification.