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Marc Tatar

Researcher at Brown University

Publications -  125
Citations -  20009

Marc Tatar is an academic researcher from Brown University. The author has contributed to research in topics: Drosophila melanogaster & Insulin receptor. The author has an hindex of 55, co-authored 123 publications receiving 18563 citations. Previous affiliations of Marc Tatar include University of Minnesota & University of Massachusetts Amherst.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

Jason G. Wood, +6 more
- 05 Aug 2004 - 
TL;DR: It is shown that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without reducing fecundity, indicating that STacs slow metazoan ageing by mechanisms that may be related to caloric restriction.
Journal ArticleDOI

A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.

Marc Tatar, +6 more
- 06 Apr 2001 - 
TL;DR: It is concluded that juvenile hormone deficiency, which results from InR signal pathway mutation, is sufficient to extend life-span, and that in flies, insulin-like ligands nonautonomously mediate aging through retardation of growth or activation of specific endocrine tissue.
Journal ArticleDOI

The endocrine regulation of aging by insulin-like signals.

Marc Tatar, +2 more
- 28 Feb 2003 - 
TL;DR: Despite the similarities among mammals and invertebrates in insulin-like peptides and their signal cascade, more research is needed to determine whether these signals control aging in the same way in all the species by the same mechanism.
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Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

Dae Sung Hwangbo, +4 more
- 03 Jun 2004 - 
TL;DR: It is demonstrated here that dFOXO regulates D. melanogaster ageing when activated in the adult pericerebral fat body and reduces expression of the Drosophila insulin-like peptide dilp-2 synthesized in neurons, and represses endogenous insulin-dependent signalling in peripheral fat body.