Marcel Smid

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: The five major molecular subtypes in breast cancer are evidently different with regard to their ability to metastasize to distant organ(s), and share biological features and pathways with their preferred distant metastatic site.

TL;DR: It is reported that a gene expression signature of Src activation is associated with late-onset bone metastasis in breast cancer, independent of hormone receptor status or breast cancer subtype.

TL;DR: This work connects four miRNAs to breast cancer progression and to several distinct biological processes involved therein.

TL;DR: The evidence suggests that stromal signals resembling those of a distant organ select for cancer cells that are primed for metastasis in that organ, thus illuminating the evolution of metastatic traits in a primary tumor and its distant metastases.