Marcella Bosco

Bio: Marcella Bosco is an academic researcher from University of Bologna. The author has contributed to research in topics: Lewis acids and bases & Alkylation. The author has an hindex of 31, co-authored 150 publications receiving 3453 citations. Previous affiliations of Marcella Bosco include University of Camerino.

Organocatalytic Asymmetric Conjugate Addition of 1,3‐Dicarbonyl Compounds to Maleimides

Abstract: The enantioselective construction of quaternary stereogenic centers bonded to four carbon atoms by efficient asymmetric methods is a great synthetic challenge, as the creation of such complex fragments is complicated by steric factors. Currently, despite the substantial progress that has been made in the last few years, only a few catalytic asymmetric C C bondforming strategies have proven to be useful for forming quaternary carbon centers. Among them, the catalytic conjugate addition of compounds with a prochiral trisubstituted nucleophilic carbon atom to b-substituted Michael acceptors constitutes an effective approach for the asymmetric construction of highly functionalized products with adjacent quaternary and tertiary carbon centers. The stereocontrolled, one-step synthesis of such important congested motifs from simple precursors is a formidable synthetic challenge, as the catalyst must provide high levels of stereoselectivity in a sterically demanding C C bond-forming process. To date, the acceptors employed in this powerful type of strategy have been enones, nitroalkenes, and unsaturated imides. Expansion of the scope of such an efficient strategy to other classes of Michael acceptors is a useful and challenging objective. Herein, we report the development of the first asymmetric direct conjugate addition of 1,3-dicarbonyl compounds to

Catalytic Functionalization of Indoles in a New Dimension

Abstract: 140 years ago Adolf von Baeyer proposed the structure of a heteroaromatic compound which revolutionized organic and medical chemistry: indole. After more than a century, indole itself and the complexity of naturally occurring indole derivatives continue to inspire and influence developments in synthetic chemistry. In particular, the ubiquitous presence of indole rings in pharmaceuticals, agrochemicals, and functional materials are testament to the ever increasing interest in the design of mild and efficient synthetic routes to functionalized indole derivatives. This Review emphasizes the achievements in the selective catalytic functionalization of indoles (C-C bond-forming processes) over the last four years.

Asymmetric aminocatalysis--gold rush in organic chemistry.

Abstract: Catalysis with chiral secondary amines (asymmetric aminocatalysis) has become a well-established and powerful synthetic tool for the chemo- and enantioselective functionalization of carbonyl compounds. In the last eight years alone, this field has grown at such an extraordinary pace that it is now recognized as an independent area of synthetic chemistry, where the goal is the preparation of any chiral molecule in an efficient, rapid, and stereoselective manner. This has been made possible by the impressive level of scientific competition and high quality research generated in this area. This Review describes this "Asymmetric Aminocatalysis Gold Rush" and charts the milestones in its development. As in all areas of science, progress depends on human effort.

Postsynthetic modification of metal–organic frameworks—a progress report

Abstract: Metal–organic frameworks (MOFs) are an important class of hybrid inorganic–organic materials. In this tutorial review, a progress report on the postsynthetic modification (PSM) of MOFs is provided. PSM refers to the chemical modification of the MOF lattice in a heterogeneous fashion. This powerful synthetic approach has grown in popularity and resulted in a number of advances in the functionalization and application of MOFs. The use of PSM to develop MOFs with improved gas sorption, catalytic activity, bioactivity, and more robust physical properties is discussed. The results reported to date clearly show that PSM is an important approach for the development and advancement of these hybrid solids.