Author
Marcelo Campos
Bio: Marcelo Campos is an academic researcher from Sao Paulo State University. The author has contributed to research in topics: Vas deferens & Nitriding. The author has an hindex of 9, co-authored 27 publications receiving 386 citations.
Topics: Vas deferens, Nitriding, Corrosion, Chloroethylclonidine, Germination
Papers
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TL;DR: Soybean plants exposed to excess Mn showed reductions in the CO2 assimilation rate and stomatal conductance, which in turn resulted in decreased shoot biomass and high activities of POD and SOD in the presence of high Mn compartmented in the roots was the main physiological responses at high Mn uptake by soybean plants.
102 citations
TL;DR: A critical overview of miRNA dysregulation in cancer is provided, reviewing the growing number of studies that have shown the importance of these small molecules and how these microRNAs can affect or be affected by genetic and epigenetic mechanisms.
Abstract: MicroRNAs are key regulators of various fundamental biological processes and, although representing only a small portion of the genome, they regulate a much larger population of target genes. Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20-23 nucleotide (nt) length that control gene expression in many cellular processes. These molecules typically reduce the stability of mRNAs, including those of genes that mediate processes in tumorigenesis, such as inflammation, cell cycle regulation, stress response, differentiation, apoptosis and invasion. MicroRNA targeting is mostly achieved through specific base-pairing interactions between the 5' end ('seed' region) of the miRNA and sites within coding and untranslated regions (UTRs) of mRNAs; target sites in the 3' UTR diminish mRNA stability. Since miRNAs frequently target hundreds of mRNAs, miRNA regulatory pathways are complex. Calin and Croce were the first to demonstrate a connection between microRNAs and increased risk of developing cancer, and meanwhile the role of microRNAs in carcinogenesis has definitively been evidenced. It needs to be considered that the complex mechanism of gene regulation by microRNAs is profoundly influenced by variation in gene sequence (polymorphisms) of the target sites. Thus, individual variability could cause patients to present differential risks regarding several diseases. Aiming to provide a critical overview of miRNA dysregulation in cancer, this article reviews the growing number of studies that have shown the importance of these small molecules and how these microRNAs can affect or be affected by genetic and epigenetic mechanisms.
98 citations
TL;DR: The results revealed previously unreported detrimental effects of Ni toxicity on soybean plants, and contribute to the understanding of several physiological, biochemical and histological mechanisms of Nioxicity in soybean, which is still poorly understood.
55 citations
TL;DR: The results indicated that the highest total dry weight value resulted from the application of IBA and Stimulate®, and that theApplication of mepiquat chloride in association with IBAand BAP reduced total dry matter production.
Abstract: Growth analysis of soybean plants treated with plant growth regulators This work aimed to verify the effect of plant growth regulators on soybean plant growth and chlorophyll content In an experiment carried out in a greenhouse, soybean plants were cultivated (Glycine max (L) Merrill cv BRS-184) in 10-liter pots containing soil from the arable layer, corrected and fertilized according to the soil analysis The treatments used were: control; GA3 100mgL-1; BAP 100mgL-1; IBA 100mgL-1; Stimulate® (IBA, GA3 and kinetin) 20mLL-1; mepiquat chloride 100mgL-1 and mepiquat chloride 100mgL-1 + BAP 100mgL-1 + IBA 100mgL-1 Treatments were applied three times at 30-day intervals Six samplings were taken at 13-day intervals The results indicated that the highest total dry weight value resulted from the application of IBA and Stimulate®, and that the application of mepiquat chloride in association with IBA and BAP reduced total dry matter production The leaf area was smaller than the control in most treatments The chlorophyll content and growth rate were slightly infl uenced by the treatments The cytokinin treatment alone or in association with other plant growth regulators retained the chlorophyll content RGR and NAR decreased from 99 days after sowing with the application of mepiquat chloride
39 citations
TL;DR: This dissertation aims to provide a history of soybean research in Brazil from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which P.J. Reis died.
Abstract: J. P. Q. Barcelos, H. P. G. Reis, C. V. Godoy, P. L. Grat~ ao, E. Furlani Junior, F. F. Putti, M. Campos and A. R. Reis* S~ ao Paulo State University – UNESP, Ilha Solteira, SP, 15385-000; Embrapa Soybean, Rodovia Carlos Jo~ ao Strass – Distrito de Warta, Londrina, 86001-970, PR; S~ ao Paulo State University – UNESP, Jaboticabal, 79560-000, SP; and S~ ao Paulo State University – UNESP, Tup~ a, 17602-496, SP, Brazil
27 citations
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01 Jan 2011
TL;DR: In this paper, the authors present a survey of the estimated costs of soil erosion, an issue of fundamental importance in view of the current worldwide discussion on soil erosion. But the authors focus on the cost of soil degradation.
Abstract: Resumen en: The aim of this study was a survey of the estimated costs of soil erosion, an issue of fundamental importance in view of the current worldwide discussion...
983 citations
TL;DR: In this article, a review of different treatment methods for removing heavy metals from the aquatic environment with a different degree of success has been presented, and the distinctive sorts of treatment strategies for the removal of the toxic metals from wastewater had been explained.
742 citations
TL;DR: The role of microRNAs in the diagnosis, prognosis, and therapy of breast cancer is discussed in this paper, where the authors present the state-of-the-art on the role of miRNAs.
Abstract: Dysregulation of microRNAs (miRNAs) is involved in the initiation and progression of several human cancers, including breast cancer (BC), as strong evidence has been found that miRNAs can act as oncogenes or tumor suppressor genes. This review presents the state of the art on the role of miRNAs in the diagnosis, prognosis, and therapy of BC. Based on the results obtained in the last decade, some miRNAs are emerging as biomarkers of BC for diagnosis (i.e., miR-9, miR-10b, and miR-17-5p), prognosis (i.e., miR-148a and miR-335), and prediction of therapeutic outcomes (i.e., miR-30c, miR-187, and miR-339-5p) and have important roles in the control of BC hallmark functions such as invasion, metastasis, proliferation, resting death, apoptosis, and genomic instability. Other miRNAs are of interest as new, easily accessible, affordable, non-invasive tools for the personalized management of patients with BC because they are circulating in body fluids (e.g., miR-155 and miR-210). In particular, circulating multiple miRNA profiles are showing better diagnostic and prognostic performance as well as better sensitivity than individual miRNAs in BC. New miRNA-based drugs are also promising therapy for BC (e.g., miR-9, miR-21, miR34a, miR145, and miR150), and other miRNAs are showing a fundamental role in modulation of the response to other non-miRNA treatments, being able to increase their efficacy (e.g., miR-21, miR34a, miR195, miR200c, and miR203 in combination with chemotherapy).
602 citations
TL;DR: This review highlights the molecular and epigenetic factors that influence MΦ polarization in both physiologic and pathologic wound healing, with particular attention to diabetic wounds.
Abstract: The healing of cutaneous wounds is dependent on the progression through distinct, yet overlapping phases of wound healing, including hemostasis, inflammation, proliferation, and resolution/remodeling. The failure of these phases to occur in a timely, progressive fashion promotes pathologic wound healing. The macrophage (MΦ) has been demonstrated to play a critical role in the inflammatory phase of tissue repair, where its dynamic plasticity allows this cell to mediate both tissue-destructive and -reparative functions. The ability to understand and control both the initiation and the resolution of inflammation is critical for treating pathologic wound healing. There are now a host of studies demonstrating that metabolic and epigenetic regulation of gene transcription can influence MΦ plasticity in wounds. In this review, we highlight the molecular and epigenetic factors that influence MΦ polarization in both physiologic and pathologic wound healing, with particular attention to diabetic wounds.
276 citations
01 Aug 2012
TL;DR: A microfluidic system for simultaneously measuring single-cell mass and cell cycle progression over multiple generations is introduced and a decrease in the growth rate variability at the G1-S phase transition is revealed, which suggests the presence of a growth rate threshold for maintaining size homeostasis.
Abstract: We introduce a microfluidic system for simultaneously measuring single cell mass and cell cycle progression over multiple generations. We use this system to obtain over 1,000 hours of growth data from mouse lymphoblast and pro-B-cell lymphoid cell lines. Cell lineage analysis revealed a decrease in the growth rate variability at the G1/S phase transition, which suggests the presence of a growth rate threshold for maintaining size homeostasis.
191 citations