M
Marcelo R. Vargas
Researcher at University of Wisconsin-Madison
Publications - 41
Citations - 4449
Marcelo R. Vargas is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Motor neuron & Astrocyte. The author has an hindex of 28, co-authored 39 publications receiving 3984 citations. Previous affiliations of Marcelo R. Vargas include Medical University of South Carolina & Pasteur Institute.
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Journal ArticleDOI
The Nrf2–ARE Pathway
Jeffrey A. Johnson,Delinda A. Johnson,Andrew D. Kraft,Marcus J. Calkins,Rebekah J. Jakel,Marcelo R. Vargas,Pei Chun Chen +6 more
TL;DR: This work hypothesizes that Nrf2–ARE activation is a novel neuroprotective pathway that confers resistance to a variety of oxidative, stress‐related, neurodegenerative insults and transplanted NRF2‐overexpressing astrocytes into the mouse striatum prior to lesioning with malonate to lead to dramatic protection against malonated neurotoxicity.
Journal ArticleDOI
Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease : Critical role for the astrocyte
Pei Chun Chen,Marcelo R. Vargas,Amar K. Pani,Richard J. Smeyne,Delinda A. Johnson,Yuet Wai Kan,Jeffrey A. Johnson +6 more
TL;DR: Stark results indicate that Nrf2 expression restricted to astrocytes is sufficient to protect against MPTP andAstrocytic modulation of the NRF2-ARE pathway is a promising target for therapeutics aimed at reducing or preventing neuronal death in PD.
Journal ArticleDOI
Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis.
TL;DR: It is demonstrated that Nrf2 activation in astrocytes is a viable therapeutic target to prevent chronic neurodegeneration.
Journal ArticleDOI
The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease
Marcus J. Calkins,Delinda A. Johnson,Jessica A. Townsend,Marcelo R. Vargas,James A. Dowell,Tracy P. Williamson,Andrew D. Kraft,Jong Min Lee,Jiang Li,Jeffrey A. Johnson +9 more
TL;DR: The current literature that suggests that Nrf2 may be a valuable therapeutic target for neurodegenerative disease is reviewed, as well as experiments that illustrate potential mechanisms of protection.
Journal ArticleDOI
A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis.
Luis Barbeito,Mariana Pehar,Patricia Cassina,Marcelo R. Vargas,Hugo Peluffo,Liliana Viera,Alvaro G. Estévez,Joseph S. Beckman +7 more
TL;DR: The comprehensive understanding of the interactions between motor neurons and glia in ALS may lead to a more accurate theory of the pathogenesis of the disease.