M
Marco Orru
Researcher at University of Cagliari
Publications - 50
Citations - 5995
Marco Orru is an academic researcher from University of Cagliari. The author has contributed to research in topics: Adenosine A2A receptor & Arterial stiffness. The author has an hindex of 30, co-authored 50 publications receiving 5511 citations. Previous affiliations of Marco Orru include National Institutes of Health & National Institute on Drug Abuse.
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Journal ArticleDOI
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.
Angelo Scuteri,Serena Sanna,Wei-Min Chen,Manuela Uda,Giuseppe Albai,James B. Strait,Samer S. Najjar,Ramaiah Nagaraja,Marco Orru,Gianluca Usala,Mariano Dei,Sandra Lai,Andrea Maschio,Fabio Busonero,Antonella Mulas,Georg Ehret,Ashley A Fink,Alan B. Weder,Richard S. Cooper,Pilar Galan,Aravinda Chakravarti,David Schlessinger,Antonio Cao,Edward G. Lakatta,Gonçalo R. Abecasis +24 more
TL;DR: In this paper, a genome-wide association scan was conducted to identify genetic variants associated with obesity-related quantitative traits in the genetically isolated population of Sardinia, and the results showed that common genetic variants in the FTO gene are associated with substantial changes in body weight.
Journal ArticleDOI
Variants in MTNR1B influence fasting glucose levels
Inga Prokopenko,Claudia Langenberg,Jose C. Florez,Jose C. Florez,Richa Saxena,Richa Saxena,Nicole Soranzo,Nicole Soranzo,Gudmar Thorleifsson,Ruth J. F. Loos,Alisa K. Manning,Anne U. Jackson,Yurii S. Aulchenko,Simon C. Potter,Michael R. Erdos,Serena Sanna,Jouke-Jan Hottenga,Eleanor Wheeler,Marika Kaakinen,Valeriya Lyssenko,Wei-Min Chen,Kourosh R. Ahmadi,Jacques S. Beckmann,Jacques S. Beckmann,Richard N. Bergman,Murielle Bochud,Lori L. Bonnycastle,Thomas A. Buchanan,Antonio Cao,Alessandra C. L. Cervino,Lachlan J. M. Coin,Francis S. Collins,Laura Crisponi,Eco J. C. de Geus,Abbas Dehghan,Panos Deloukas,Alex S. F. Doney,Paul Elliott,Nelson B. Freimer,Vesela Gateva,Christian Herder,Albert Hofman,Thomas Edward Hughes,Sarah E. Hunt,Thomas Illig,Michael Inouye,Bo Isomaa,Toby Johnson,Toby Johnson,Toby Johnson,Augustine Kong,Maria Krestyaninova,Johanna Kuusisto,Markku Laakso,Noha Lim,Ulf Lindblad,Cecilia M. Lindgren,O. T. McCann,Karen L. Mohlke,Andrew D. Morris,Silvia Naitza,Marco Orru,Colin N. A. Palmer,Anneli Pouta,Joshua C. Randall,Wolfgang Rathmann,Jouko Saramies,Paul Scheet,Laura J. Scott,Angelo Scuteri,Stephen J. Sharp,Eric J.G. Sijbrands,Jan H. Smit,Kijoung Song,Valgerdur Steinthorsdottir,Heather M. Stringham,Tiinamaija Tuomi,Jaakko Tuomilehto,André G. Uitterlinden,Benjamin F. Voight,Benjamin F. Voight,Dawn M. Waterworth,H-Erich Wichmann,Gonneke Willemsen,Jacqueline C.M. Witteman,Xin Yuan,Jing Hua Zhao,Eleftheria Zeggini,David Schlessinger,Manjinder S. Sandhu,Manjinder S. Sandhu,Dorret I. Boomsma,Manuela Uda,Tim D. Spector,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,David Altshuler,David Altshuler,Peter Vollenweider,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Edward G. Lakatta,Gérard Waeber,Caroline S. Fox,Caroline S. Fox,Leena Peltonen,Leena Peltonen,Leif Groop,Vincent Mooser,L. Adrienne Cupples,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Michael Boehnke,Inês Barroso,Cornelia M. van Duijn,Josée Dupuis,Richard M. Watanabe,Kari Stefansson,Kari Stefansson,Mark I. McCarthy,Mark I. McCarthy,Nicholas J. Wareham,James B. Meigs,Gonçalo R. Abecasis +124 more
TL;DR: Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten genome-wide association scans, and previous associations of fasting glucose with variants at the G6PC2 and GCK loci are confirmed.
Journal ArticleDOI
Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians
Giuseppe Pilia,Wei-Min Chen,Angelo Scuteri,Marco Orru,Giuseppe Albai,Mariano Dei,Sandra Lai,Gianluca Usala,Monica Lai,Paola Loi,Cinzia Mameli,Loredana Vacca,Manila Deiana,Nazario Olla,Marco Masala,Antonio Cao,Samer S. Najjar,Antonio Terracciano,Timur Nedorezov,Alexei A. Sharov,Alan B. Zonderman,Gonçalo R. Abecasis,Paul T. Costa,Edward G. Lakatta,David Schlessinger +24 more
TL;DR: Significant evidence for heritability of many medically important traits, including cardiovascular function and personality is found, and evidence for heterogeneity by age and sex suggests that models allowing for these differences will be important in mapping quantitative traits.
Journal ArticleDOI
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
Louise V. Wain,Germaine C. Verwoert,Paul F. O'Reilly,Gang Shi,Toby Johnson,Andrew D. Johnson,Murielle Bochud,Kenneth Rice,Peter Henneman,Albert V. Smith,Georg Ehret,Georg Ehret,Georg Ehret,Najaf Amin,Martin G. Larson,Martin G. Larson,Vincent Mooser,David Hadley,David Hadley,Marcus Doerr,Joshua C. Bis,Thor Aspelund,Tõnu Esko,A. Cecile J.W. Janssens,Jing Hua Zhao,Simon Heath,Maris Laan,Jingyuan Fu,Giorgio Pistis,Jian'an Luan,Pankaj Arora,Gavin Lucas,Nicola Pirastu,Irene Pichler,Anne U. Jackson,Rebecca J. Webster,Feng Zhang,John F. Peden,Helena Schmidt,Toshiko Tanaka,Harry Campbell,Wilmar Igl,Yuri Milaneschi,Jouke-Jan Hottenga,Veronique Vitart,Daniel I. Chasman,Stella Trompet,Jennifer L. Bragg-Gresham,Behrooz Z. Alizadeh,John C. Chambers,John C. Chambers,Xiuqing Guo,Terho Lehtimäki,Brigitte Kuehnel,Lorna M. Lopez,Ozren Polasek,Mladen Boban,Christopher P. Nelson,Alanna C. Morrison,Vasyl Pihur,Santhi K. Ganesh,Albert Hofman,Suman Kundu,Francesco U.S. Mattace-Raso,Fernando Rivadeneira,Eric J.G. Sijbrands,André G. Uitterlinden,Shih-Jen Hwang,Ramachandran S. Vasan,Thomas J. Wang,Sven Bergmann,Peter Vollenweider,Gérard Waeber,Jaana Laitinen,Anneli Pouta,Paavo Zitting,Wendy L. McArdle,Heyo K. Kroemer,Uwe Voelker,Henry Voelzke,Nicole L. Glazer,Kent D. Taylor,Tamara B. Harris,Helene Alavere,Toomas Haller,Aime Keis,Mari-Liis Tammesoo,Yurii S. Aulchenko,Inês Barroso,Kay-Tee Khaw,Pilar Galan,Serge Hercberg,Mark Lathrop,Susana Eyheramendy,Elin Org,Siim Sõber,Xiaowen Lu,Ilja M. Nolte,Brenda W.J.H. Penninx,Tanguy Corre,Corrado Masciullo,Cinzia Sala,Leif Groop,Benjamin F. Voight,Olle Melander,Christopher J. O'Donnell,Veikko Salomaa,Adamo Pio D'Adamo,Antonella Fabretto,Flavio Faletra,Sheila Ulivi,Fabiola M. Del Greco,Maurizio F. Facheris,Francis S. Collins,Richard N. Bergman,John Beilby,Joseph Hung,A. William Musk,Massimo Mangino,So-Youn Shin,Nicole Soranzo,Hugh Watkins,Anuj Goel,Anders Hamsten,Pierre Gider,Marisa Loitfelder,Marion Zeginigg,Dena G. Hernandez,Samer S. Najjar,Pau Navarro,Sarah H. Wild,Anna Maria Corsi,Andrew B. Singleton,Eco J. C. de Geus,Gonneke Willemsen,Alex Parker,Lynda M. Rose,Brendan M. Buckley,David J. Stott,Marco Orru,Manuela Uda,Melanie M. van der Klauw,Weihua Zhang,Xinzhong Li,James Scott,Yii-Der Ida Chen,Gregory L. Burke,Mika Kähönen,Jorma Viikari,Angela Doering,Thomas Meitinger,Gail Davies,John M. Starr,Valur Emilsson,Andrew S. Plump,Jan H.N. Lindeman,Peter A C 't Hoen,Inke R. Koenig,Janine F. Felix,Robert Clarke,Jemma C. Hopewell,Halit Ongen,Monique M.B. Breteler,Stéphanie Debette,Anita L. DeStefano,Myriam Fornage,Gary F. Mitchell,Nicholas L. Smith,Hilma Holm,Kari Stefansson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Nilesh J. Samani,Michael Preuss,Igor Rudan,Caroline Hayward,Ian J. Deary,H-Erich Wichmann,Olli T. Raitakari,Walter Palmas,Jaspal S. Kooner,Jaspal S. Kooner,Ronald P. Stolk,J. Wouter Jukema,Alan F. Wright,Dorret I. Boomsma,Stefania Bandinelli,Ulf Gyllensten,James F. Wilson,Luigi Ferrucci,Reinhold Schmidt,Martin Farrall,Tim D. Spector,Lyle J. Palmer,Jaakko Tuomilehto,Arne Pfeufer,Paolo Gasparini,David S. Siscovick,David Altshuler,Ruth J. F. Loos,Daniela Toniolo,Harold Snieder,Christian Gieger,Pierre Meneton,Nicholas J. Wareham,Ben A. Oostra,Andres Metspalu,Lenore J. Launer,Rainer Rettig,David P. Strachan,Jacques S. Beckmann,Jacqueline C. M. Witteman,Jeanette Erdmann,Ko Willems van Dijk,Eric Boerwinkle,Michael Boehnke,Paul M. Ridker,Marjo-Riitta Järvelin,Aravinda Chakravarti,Gonçalo R. Abecasis,Vilmundur Gudnason,Christopher Newton-Cheh,Daniel Levy,Patricia B. Munroe,Bruce M. Psaty,Mark J. Caulfield,Dabeeru C. Rao,Martin D. Tobin,Paul Elliott,Cornelia M. van Duijn +229 more
TL;DR: Findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP, as well as two new MAP loci associated with both of these traits.
Journal ArticleDOI
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
Dan E. Arking,Sara L. Pulit,Sara L. Pulit,Sara L. Pulit,Lia Crotti,Pim van der Harst,Patricia B. Munroe,Tamara T. Koopmann,Nona Sotoodehnia,Elizabeth J. Rossin,Elizabeth J. Rossin,Michael Morley,Xinchen Wang,Xinchen Wang,Andrew D. Johnson,Alicia Lundby,Alicia Lundby,Daniel F. Gudbjartsson,Peter A. Noseworthy,Peter A. Noseworthy,Mark Eijgelsheim,Yuki Bradford,Kirill Tarasov,Marcus Dörr,Martina Müller-Nurasyid,Annukka M. Lahtinen,Ilja M. Nolte,Albert V. Smith,Joshua C. Bis,Aaron Isaacs,Stephen Newhouse,Daniel S. Evans,Wendy S. Post,Daryl Waggott,Leo-Pekka Lyytikäinen,Andrew A. Hicks,Lewin Eisele,David Ellinghaus,Caroline Hayward,Pau Navarro,Sheila Ulivi,Toshiko Tanaka,David J. Tester,Stéphanie Chatel,Stefan Gustafsson,Stefan Gustafsson,Meena Kumari,Richard W Morris,Åsa Torinsson Naluai,Sandosh Padmanabhan,Alexander Kluttig,Bernhard Strohmer,Andrie G. Panayiotou,María Dolores Torres,Michael Knoflach,Jaroslav A. Hubacek,Kamil Slowikowski,Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,Runjun D. Kumar,Tamara B. Harris,Lenore J. Launer,Alan R. Shuldiner,Alan R. Shuldiner,Alvaro Alonso,Joel S. Bader,Georg Ehret,Hailiang Huang,Hailiang Huang,W. H. Linda Kao,James B. Strait,Peter W. Macfarlane,Morris Brown,Mark J. Caulfield,Nilesh J. Samani,Florian Kronenberg,Johann Willeit,J. Gustav Smith,J. Gustav Smith,J. Gustav Smith,Karin Halina Greiser,Karin Halina Greiser,Henriette E. Meyer zu Schwabedissen,Karl Werdan,Massimo Carella,Leopoldo Zelante,Susan R. Heckbert,Bruce M. Psaty,Bruce M. Psaty,Jerome I. Rotter,Ivana Kolcic,Ozren Polasek,Alan F. Wright,Maura Griffin,Mark J. Daly,Mark J. Daly,David O. Arnar,Hilma Holm,Unnur Thorsteinsdottir,Joshua C. Denny,Dan M. Roden,Rebecca L. Zuvich,Valur Emilsson,Andrew S. Plump,Martin G. Larson,Martin G. Larson,Christopher J. O'Donnell,Christopher J. O'Donnell,Xiaoyan Yin,Xiaoyan Yin,Marco Bobbo,Adamo Pio D'Adamo,Annamaria Iorio,Gianfranco Sinagra,Angel Carracedo,Steven R. Cummings,Mike A. Nalls,Antti Jula,Kimmo Kontula,Annukka Marjamaa,Lasse Oikarinen,Markus Perola,Markus Perola,Markus Perola,Kimmo Porthan,Raimund Erbel,Per Hoffmann,Per Hoffmann,Karl-Heinz Jöckel,Hagen Kälsch,Markus M. Nöthen,Marcel den Hoed,Marcel den Hoed,Ruth J. F. Loos,Ruth J. F. Loos,Dag S. Thelle,Dag S. Thelle,Christian Gieger,Thomas Meitinger,Siegfried Perz,Annette Peters,Hanna Prucha,Moritz F. Sinner,Melanie Waldenberger,Rudolf A. de Boer,Lude Franke,Pieter A. van der Vleuten,Britt M. Beckmann,Eimo Martens,Abdennasser Bardai,Nynke Hofman,Arthur A.M. Wilde,Elijah R. Behr,Chrysoula Dalageorgou,John R. Giudicessi,Argelia Medeiros-Domingo,Julien Barc,Florence Kyndt,Vincent Probst,Alice Ghidoni,Roberto Insolia,Robert M. Hamilton,Stephen W. Scherer,Jeffrey Brandimarto,Kenneth B. Margulies,Christine E. Moravec,Fabiola Del Greco M,Christian Fuchsberger,Jeffrey R. O'Connell,Wai K. Lee,Graham Watt,Harry Campbell,Sarah H Wild,Nour Eddine El Mokhtari,Norbert Frey,Folkert W. Asselbergs,Folkert W. Asselbergs,Irene Mateo Leach,Gerjan Navis,Maarten P. van den Berg,Dirk J. van Veldhuisen,Manolis Kellis,Manolis Kellis,Bouwe P. Krijthe,Oscar H. Franco,Albert Hofman,Jan A. Kors,André G. Uitterlinden,Jacqueline C.M. Witteman,Lyudmyla Kedenko,Claudia Lamina,Ben A. Oostra,Gonçalo R. Abecasis,Edward G. Lakatta,Antonella Mulas,Marco Orru,David Schlessinger,Manuela Uda,Marcello Ricardo Paulista Markus,Uwe Völker,Harold Snieder,Tim D. Spector,Johan Ärnlöv,Johan Ärnlöv,Lars Lind,Johan Sundström,Ann-Christine Syvänen,Mika Kivimäki,Mika Kähönen,Nina Mononen,Olli T. Raitakari,Jorma S. A. Viikari,Vera Adamkova,Stefan Kiechl,Maria Brion,Andrew N. Nicolaides,Bernhard Paulweber,Johannes Haerting,Anna F. Dominiczak,Fredrik Nyberg,Fredrik Nyberg,Peter H. Whincup,Aroon D. Hingorani,Jean-Jacques Schott,Connie R. Bezzina,Erik Ingelsson,Erik Ingelsson,Luigi Ferrucci,Paolo Gasparini,James F. Wilson,Igor Rudan,Andre Franke,Thomas W. Mühleisen,Peter P. Pramstaller,Terho Lehtimäki,Andrew D. Paterson,Afshin Parsa,Yongmei Liu,Cornelia M. van Duijn,David S. Siscovick,Vilmundur Gudnason,Yalda Jamshidi,Veikko Salomaa,Stephan B. Felix,Serena Sanna,Marylyn D. Ritchie,Bruno H. Stricker,Kari Stefansson,Laurie A. Boyer,Thomas P. Cappola,Jesper V. Olsen,Kasper Lage,Peter J. Schwartz,Stefan Kääb,Aravinda Chakravarti,Michael J. Ackerman,Arne Pfeufer,Paul I.W. de Bakker,Christopher Newton-Cheh,Christopher Newton-Cheh +260 more
TL;DR: In this paper, the authors identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization.