M
Marcos R.M. Fontes
Researcher at Sao Paulo State University
Publications - 135
Citations - 4356
Marcos R.M. Fontes is an academic researcher from Sao Paulo State University. The author has contributed to research in topics: Snake venom & Nuclear localization sequence. The author has an hindex of 31, co-authored 128 publications receiving 3823 citations. Previous affiliations of Marcos R.M. Fontes include University of São Paulo & St. Vincent's Institute of Medical Research.
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Journal ArticleDOI
Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha
TL;DR: The nucleoplasmin NLS-importin-alpha complex shows, for the first time, the mode of binding of bipartite NLSs to the receptor, and the structures explain the structural basis for binding of diverse NLSS to the sole receptor protein.
Journal ArticleDOI
Structural Biology and Regulation of Protein Import into the Nucleus
Mary Christie,Chiung-Wen Chang,Chiung-Wen Chang,Gergely Róna,Kate Smith,Alastair G. Stewart,Agnes A.S. Takeda,Marcos R.M. Fontes,Murray Stewart,Beáta G. Vértessy,Jade K. Forwood,Bostjan Kobe +11 more
TL;DR: The structural basis of the principal nuclear import pathways and the molecular basis of their regulation are reviewed and post-translational modifications, particularly phosphorylation, constitute key regulatory mechanisms operating in these pathways.
Journal ArticleDOI
Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha.
Marcos R.M. Fontes,Marcos R.M. Fontes,Trazel Teh,Trazel Teh,David A. Jans,David A. Jans,Ross I. Brinkworth,Bostjan Kobe,Bostjan Kobe +8 more
TL;DR: The available data allow us to draw general conclusions about the specificity of NLS binding by importin-α and facilitate an improved definition of the consensus sequence of a conventional basic/bipartite NLS that can be used to identify novel nuclear proteins.
Journal ArticleDOI
Rosmarinic acid, a new snake venom phospholipase A2 inhibitor from Cordia verbenacea (Boraginaceae): antiserum action potentiation and molecular interaction
Fábio Kiss Ticli,Hage Li,R. S. Cambraia,Paulo Pereira,Angelo J. Magro,Marcos R.M. Fontes,Rodrigo G. Stábeli,Giglio,Suzelei C. França,Andreimar M. Soares,Suely Vilela Sampaio +10 more
TL;DR: The pure compound potentiated the ability of the commercial equine polyvalent antivenom in neutralizing lethal and myotoxic effects of the crude venom and of isolated PLA2s in experimental models.
Journal ArticleDOI
Structural and functional characterization of BnSP-7, a Lys49 myotoxic phospholipase A(2) homologue from Bothrops neuwiedi pauloensis venom.
Andreimar M. Soares,Andreimar M. Soares,Renata Guerra-Sá,Caroline Ribeiro de Borja-Oliveira,Veridiana M. Rodrigues,Léa Rodrigues-Simioni,Vanderlei Rodrigues,Marcos R.M. Fontes,Bruno Lomonte,José María Gutiérrez,José Roberto Giglio +10 more
TL;DR: BnSP-7, a Lys49 myotoxic phospholipase A(2) homologue from Bothrops neuwiedi pauloensis venom, was structurally and functionally characterized and displayed bactericidal activity and promoted the blockage of the neuromuscular contraction of the chick biventer cervicis muscle.