M
Marcus A. Horwitz
Researcher at University of California, Los Angeles
Publications - 156
Citations - 17316
Marcus A. Horwitz is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Mycobacterium tuberculosis & Legionella pneumophila. The author has an hindex of 71, co-authored 152 publications receiving 16497 citations. Previous affiliations of Marcus A. Horwitz include Rockefeller University & Oklahoma State University Center for Health Sciences.
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Journal ArticleDOI
Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited.
TL;DR: Findings suggest that M. tuberculosis retards the maturation of its phagosome along the endosomal-lysosomal pathway and resides in a compartment with endosome, as opposed to lysosomal, characteristics; and the intraphagosomal pathway, i.e., the pathway followed by several intracellular parasites that inhibit phagosomes-lysOSome fusion, is heterogeneous.
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The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes.
TL;DR: The capacity of L. pneumophila to inhibit phagosome-lysosome fusion may be a critical mechanism by which the bacterium resists monocyte microbicidal effects.
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Legionnaires' Disease Bacterium (Legionella pneumophila) Multiplies Intracellularly in Human Monocytes
TL;DR: Findings indicate that L. pneumophila falls into a select category of bacterial pathogens that evade host defenses by parasitizing monocytes, and it remains to be determined whether cell-mediated immunity plays a dominant role in host defense against L.neumophila as it does against other intracellular pathogens.
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Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes.
TL;DR: The L. pneumophila- containing vacuole has certain features in common with other intracellular organisms that inhibit phagosome-lysosome fusion; these organisms may share a common mechanism for vacuoles formation and inhibition of phagosomes-lysOSome fusion.
Journal Article
Phagocytosis of Mycobacterium tuberculosis is mediated by human monocyte complement receptors and complement component C3.
TL;DR: It is demonstrated that human monocyte CR1 and CR3 mediate phagocytosis of M. tuberculosis and C component C3 in serum is acting as the major bacterium-bound ligand.