M
Marcus J. Korth
Researcher at University of Washington
Publications - 62
Citations - 6870
Marcus J. Korth is an academic researcher from University of Washington. The author has contributed to research in topics: Virus & Interferon. The author has an hindex of 36, co-authored 61 publications receiving 6272 citations. Previous affiliations of Marcus J. Korth include University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Into the Eye of the Cytokine Storm
Jennifer R. Tisoncik,Marcus J. Korth,Cameron P. Simmons,Jeremy Farrar,Thomas R. Martin,Michael G. Katze +5 more
TL;DR: How high-throughput genomic methods are revealing the importance of the kinetics of cytokine gene expression and the remarkable degree of redundancy and overlap in cytokine signaling is highlighted.
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Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
Michael Gale,Marcus J. Korth,Norina M. Tang,Seng Lai Tan,Deborah A. Hopkins,Thomas E. Dever,Stephen J. Polyak,David R. Gretch,Michael G. Katze +8 more
TL;DR: It is reported that NS5A represses PKR through a direct interaction with the protein kinase catalytic domain and that both PKR repression and interaction requires the ISDR, suggesting inactivation of PKR may be one mechanism by which HCV avoids the antiviral effects of IFN.
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Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation
Michael Gale,Collin M. Blakely,Bart Kwieciszewski,Seng Lai Tan,Michelle L. Dossett,Norina M. Tang,Marcus J. Korth,Stephen J. Polyak,David R. Gretch,Michael G. Katze +9 more
TL;DR: Results indicate that mutations within the PKR-binding region of NS5A, including those within the ISDR, can disrupt the NS5a-PKR interaction, possibly rendering HCV sensitive to the antiviral effects of interferon.
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Control of PERK eIF2α kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK
Wei Yan,Christopher L. Frank,Marcus J. Korth,Bryce L. Sopher,Isabel Novoa,David Ron,Michael G. Katze +6 more
TL;DR: It is found that the stress of unfolded proteins in the endoplasmic reticulum (ER) activates P58IPK gene transcription through an ER stress-response element in its promoter region and plays a functional role in the expression of downstream markers of PERK activity in the later phase of the ER-stress response.
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Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance
Angela L. Rasmussen,Atsushi Okumura,Atsushi Okumura,Martin T. Ferris,Richard Green,Friederike Feldmann,Sara M. Kelly,Dana P. Scott,David Safronetz,Elaine Haddock,Rachel A. LaCasse,Matthew J. Thomas,Pavel Sova,Victoria S. Carter,Jeffrey M. Weiss,Darla R. Miller,Ginger D. Shaw,Marcus J. Korth,Mark T. Heise,Ralph S. Baric,Fernando Pardo-Manuel de Villena,Heinz Feldmann,Michael G. Katze +22 more
TL;DR: It is shown that mice from the Collaborative Cross panel of recombinant inbred mice exhibit distinct disease phenotypes after mouse-adapted Ebola virus infection, suggesting this panel of mice could prove valuable for preliminary screens of candidate therapeutics and vaccines.