Marcus J. Moeller

TL;DR: A transgenic mouse line that expresses Cre recombinase exclusively in podocytes is reported, and Histological analysis of the kidneys showed that β‐gal expression was confined to podocytes.

TL;DR: Mammalian FAT1 is identified as a proximal element of a signaling pathway that determines both cellular polarity in the plane of the monolayer and directed actin‐dependent cell motility.

TL;DR: A genetic cell lineage-mapping study with a novel transgenic mouse model was performed to investigate whether visceral glomerular epithelial cells, termed podocytes, are precursors of cells that populate cellular crescents, indicating that podocytes underwent profound phenotypic changes in this nephritis model.

TL;DR: Two truly podocytes-specific promoters were identified that drive transgene expression in podocytes without expression in extrarenal tissues in adult or embryonic mice and a 2.5-kb NPHS2 promoter fragment may be useful for podocyte-specific transgenic expression whenextrarenal expression of a transgenes is problematic.

TL;DR: Identical patterns of beta-galactosidase expression were observed in multiple transgenic founders, suggesting that the expression pattern observed was independent of the site of transgene integration, and transgenes regulated by this promoter should be useful for studying the biology of gene products that regulate podocyte phenotype and function.