M
Mareike Kelkel
Publications - 9
Citations - 614
Mareike Kelkel is an academic researcher. The author has contributed to research in topics: Biological activity & Cancer. The author has an hindex of 8, co-authored 9 publications receiving 540 citations.
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Antioxidant and anti-proliferative properties of lycopene
TL;DR: A review of the current knowledge about the cellular action of lycopene and the molecular targets responsible for its remarkable chemopreventive and anti-proliferative activity provides evidence for the biological activity of some oxidized Lycopene metabolites, which seem to be partially responsible for the strong and manifold anti-cancer potential of lyCopene.
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Gold from the sea: marine compounds as inhibitors of the hallmarks of cancer.
TL;DR: This work focuses here on selected marine compounds that act on the six hallmarks of cancer presented namely self-sufficiency in growth signals, insensitivity to anti-growth signals, evasion of apoptosis, limitless replication, sustained angiogenesis and tissue invasion and metastasis.
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Potential of the dietary antioxidants resveratrol and curcumin in prevention and treatment of hematologic malignancies.
TL;DR: Evidence is provided that both resveratrol and curcumin possess huge potential for application as both chemopreventive agents and anticancer drugs and might represent promising candidates for future treatment of leukemia.
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Selective antimicrobial activity associated with sulfur nanoparticles.
Thomas Schneider,Alexander Baldauf,Lalla Aïcha Ba,Vincent Jamier,Khairan Khairan,Mohammed-Bader Sarakbi,Nico Reum,Marc Schneider,Anne Röseler,Katja Becker,Torsten Burkholz,Paul G. Winyard,Mareike Kelkel,Marc Diederich,Claus Jacob +14 more
TL;DR: Together, the ease of production of the sulfur nanoparticles, their chemical stability in aqueous dispersion, amenable physical properties and selective toxicity, turn sulphur nanoparticles into promising antimicrobial prototypes for medical as well as agricultural applications.
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ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis
Mareike Kelkel,Claudia Cerella,Fabienne Mack,Thomas Schneider,Claus Jacob,Marc Schumacher,Mario Dicato,Marc Diederich +7 more
TL;DR: Evidence is provided that c-jun N-terminal kinase, which is activated early in response to diallyl tetrasulfide treatment, mediates multisite phosphorylation and subsequent proteolysis of the anti-apoptotic protein B-cell lymphoma 2 to represent the missing link connecting early microtubule inactivation to the induction of apoptosis.