M
Margit Mahlapuu
Researcher at Sahlgrenska University Hospital
Publications - 83
Citations - 5741
Margit Mahlapuu is an academic researcher from Sahlgrenska University Hospital. The author has contributed to research in topics: Nonalcoholic fatty liver disease & Protein kinase A. The author has an hindex of 29, co-authored 78 publications receiving 4695 citations. Previous affiliations of Margit Mahlapuu include University of Gothenburg & Arla Foods.
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Journal ArticleDOI
Antimicrobial Peptides: An Emerging Category of Therapeutic Agents
Margit Mahlapuu,Margit Mahlapuu,Joakim Håkansson,Lovisa Ringstad,Camilla Björn,Camilla Björn +5 more
TL;DR: An overview of the biological role, classification, and mode of action of AMPs is provided, the opportunities and challenges to develop these peptides for clinical applications are discussed, and the innovative formulation strategies for application are reviewed.
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Forkhead transcription factors: Key players in development and metabolism
Peter Carlsson,Margit Mahlapuu +1 more
TL;DR: Forkhead proteins are not among the largest transcription factor families, but display a remarkable functional diversity and are involved in a wide variety of biological processes.
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Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations.
TL;DR: It is shown that Foxf1 heterozygote perinatal mortality is around 90%.
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The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle.
Brian R. Barnes,Stefan L. Marklund,Tatiana L. Steiler,Mark R. Walter,Göran Hjälm,Valérie Amarger,Margit Mahlapuu,Ying Leng,Carina Johansson,Dana Galuska,Kerstin Lindgren,Magnus Åbrink,David Stapleton,Juleen R. Zierath,Leif Andersson,Leif Andersson +15 more
TL;DR: The results validate the muscle-specific AMPK γ3 isoform as a therapeutic target for prevention and treatment of insulin resistance and identify the R225Q mutation associated with higher basal AMPK activity and diminished AMP dependence.
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The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm
TL;DR: The murine Foxf1 gene encodes a forkhead transcription factor expressed in extra-embryonic and lateral plate mesoderm and later in splanchnic mesenchyme surrounding the gut and its derivatives and it is shown that mutant embryos die at midgestation due to defects in mesodermal differentiation and cell adhesion.