Margot Fonteyne

TL;DR: This paper aims at reviewing the use of Raman and NIR spectroscopy in the PAT setting, i.e., during processing, with special emphasis in pharmaceutics and dosage forms.

TL;DR: The results showed that the quality of granules and tablets can be optimized by adjusting specific process variables during a granulation process using a continuous twin screw granulator.

TL;DR: This review explores the implementation of PAT tools within continuous pharmaceutical processes (i.e., blending, spray drying, roller compaction, twin-screw granulation and compression), focusing on both opportunities and challenges.

TL;DR: This manuscript evaluates strengths and weaknesses of several complementary Process Analytical Technology (PAT) tools implemented in a continuous wet granulation process, which is part of a fully continuous from powder-to-tablet production line.

TL;DR: Evaluated twin screw granulation techniques found that implementing additional kneading elements or cutters in the final section of the screw configuration was not beneficial, and granulation with only TME or SME had limited impact on the width of the PSD.