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Author

Maria Agapova

Other affiliations: Systems Research Institute
Bio: Maria Agapova is an academic researcher from University of Washington. The author has contributed to research in topics: Cost effectiveness & Population. The author has an hindex of 8, co-authored 13 publications receiving 280 citations. Previous affiliations of Maria Agapova include Systems Research Institute.

Papers
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Journal ArticleDOI
TL;DR: The health economics of PRT could be an important consideration in decision making for this technology because of the potential broad‐spectrum risk reduction capability ofPRT.

73 citations

Journal ArticleDOI
TL;DR: The objective of this study was to report the results of routine testing and risk factor data from allogeneic blood donors.

43 citations

Journal ArticleDOI
TL;DR: The cost‐effectiveness of seven testing strategies was evaluated against no testing and hierarchically in incremental analysis, and component‐specific strategies are based on screening platelet‐containing donations.

37 citations

Journal ArticleDOI
TL;DR: In the original paper, there was an error in the legend for Figure 3, donor and nondonor lines were reversed and the legend is provided with the correct legend.
Abstract: In the original paper, there was an error in Figure 3. In the legend for Figure 3, donor and nondonor lines were reversed. Here, we provide Figure 3 with the correct legend.

36 citations

Journal ArticleDOI
01 Aug 2011-PLOS ONE
TL;DR: Host HLA may be associated with the outcome of WNV disease; HLA-A*68 and C*08 might function as “susceptible” alleles, whereas H LA-B*40 and C-03 might functionAs “protective”alleles.
Abstract: Background West Nile virus (WNV) infection is asymptomatic in most individuals, with a minority developing symptoms ranging from WNV fever to serious neuroinvasive disease. This study investigated the impact of host HLA on the outcome of WNV disease. Methods A cohort of 210 non-Hispanic mostly white WNV(+) subjects from Canada and the U.S. were typed for HLA-A, B, C, DP, DQ, and DR. The study subjects were divided into three WNV infection outcome groups: asymptomatic (AS), symptomatic (S), and neuroinvasive disease (ND). Allele frequency distribution was compared pair-wise between the AS, S, and ND groups using χ2 and Fisher's exact tests and P values were corrected for multiple comparisons (Pc). Allele frequencies were compared between the groups and the North American population (NA) used as a control group. Logistic regression analysis was used to evaluate the potential synergistic effect of age and HLA allele phenotype on disease outcome. Results The alleles HLA-A*68, C*08 and DQB*05 were more frequently associated with severe outcomes (ND vs. AS, P(A*68) = 0.013/Pc = 0.26, P(C*08) = 0.0075/Pc = 0.064, and P(DQB1*05) = 0.029/Pc = 0.68), However the apparent DQB1*05 association was driven by age. The alleles HLA-B*40 and C*03 were more frequently associated with asymptomatic outcome (AS vs. S, P(B*40) = 0.021/Pc = 0.58 and AS vs. ND P(C*03) = 0.039/Pc = 0.64) and their frequencies were lower within WNV(+) subjects with neuroinvasive disease than within the North American population (NA vs. S, P(B*40) = 0.029 and NA vs. ND, P(C*03) = 0.032). Conclusions Host HLA may be associated with the outcome of WNV disease; HLA-A*68 and C*08 might function as "susceptible" alleles, whereas HLA-B*40 and C*03 might function as "protective" alleles.

34 citations


Cited by
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01 Sep 1999
TL;DR: Attention is drawn to the following places, which may be of interest for search: Transmission systems for measured values, control or similar signals.
Abstract: References Informative references Attention is drawn to the following places, which may be of interest for search: Transmission systems for measured values, control or similar signals G08C Speech analysis or synthesis G10L Coding, decoding or code conversion H03M Broadcast communication H04H Multiplex communication H04J Secret communication H04K Transmission of digital information H04L Telephonic communication H04M Pictorial communication H04N Wireless communication networks H04W

283 citations

Journal ArticleDOI
TL;DR: The biology of the virus is briefly touched upon and a comprehensive review regarding recent discoveries about virus transmission, virus acquisition, and human infection and disease is provided.
Abstract: SUMMARY West Nile Virus was introduced into the Western Hemisphere during the late summer of 1999 and has been causing significant and sometimes severe human diseases since that time. This article briefly touches upon the biology of the virus and provides a comprehensive review regarding recent discoveries about virus transmission, virus acquisition, and human infection and disease.

267 citations

Journal ArticleDOI
TL;DR: This review gives an overview of the Mirasol PRT System, summarizing the mechanism of action, toxicology profile, pathogen reduction performance and clinical efficacy of the process.
Abstract: Bacterial contamination and emerging infections combined with increased international travel pose a great risk to the safety of the blood supply. Tests to detect the presence of infection in a donor have a 'window period' during which infections cannot be detected but the donor may be infectious. Agents and their transmission routes need to be recognized before specific tests can be developed. Pathogen reduction of blood components represents a means to address these concerns and is a proactive approach for the prevention of transfusion-transmitted diseases. The expectation of a pathogen reduction system is that it achieves high enough levels of pathogen reduction to reduce or prevent the likelihood of disease transmission while preserving adequate cell and protein quality. In addition the system needs to be non-toxic, non-mutagenic and should be simple to use. The Mirasol® Pathogen Reduction Technology (PRT) System for Platelets and Plasma uses riboflavin (vitamin B2) plus UV light to induce damage in nucleic acid-containing agents. The system has been shown to be effective against clinically relevant pathogens and inactivates leukocytes without significantly compromising the efficacy of the product or resulting in product loss. Riboflavin is a naturally occurring vitamin with a well-known and well-characterized safety profile. The same methodology is currently under development for the treatment of whole blood, making pathogen reduction of all blood products using one system achievable. This review gives an overview of the Mirasol PRT System, summarizing the mechanism of action, toxicology profile, pathogen reduction performance and clinical efficacy of the process.

179 citations

Journal ArticleDOI
TL;DR: This review will address the response of the blood banking community to the major transfusion-transmitted infectious diseases (TTIDs) over the past 50 years, during which time the evolving appreciation of risk and progress in addressing TTIDs has been documented by more than 1000 publications in TRANSFUSION.

164 citations