M
Maria Alexandra Brito
Researcher at University of Lisbon
Publications - 89
Citations - 4796
Maria Alexandra Brito is an academic researcher from University of Lisbon. The author has contributed to research in topics: Blood–brain barrier & Oxidative stress. The author has an hindex of 39, co-authored 84 publications receiving 4042 citations. Previous affiliations of Maria Alexandra Brito include Technical University of Lisbon & University of Porto.
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Looking at the blood-brain barrier: molecular anatomy and possible investigation approaches.
TL;DR: In this review, the unique properties of brain microvascular endothelial cells and intercellular junctions are examined and some of the experimental approaches that can be used to monitor BBB properties and function in a variety of conditions and have allowed recent advances in BBB knowledge are summarized.
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Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases
Ana L. Cardoso,Adelaide Fernandes,Juan Antonio Aguilar-Pimentel,Martin Hrabé de Angelis,Joana R. Guedes,Maria Alexandra Brito,Saida Ortolano,Giovambattista Pani,Sophia Athanasopoulou,Efstathios S. Gonos,Markus Schosserer,Johannes Grillari,Pärt Peterson,Bilge Guvenc Tuna,Soner Dogan,Angelika Meyer,Ronald van Os,Anne-Ulrike Trendelenburg +17 more
TL;DR: Biomarker panels for frailty would be of high value and better than single markers.
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Neurovascular Unit: a Focus on Pericytes
TL;DR: The neurovascular unit composition and the interplay between the diverse components, addressing pericytes with a particular detail are reviewed, addressing this cells with a great potential for therapy.
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Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier
Michael Bernas,Filipa L. Cardoso,Sarah Daley,Martin E. Weinand,Alexandre Rainha Campos,António Gonçalves Ferreira,James B. Hoying,Marlys H. Witte,Dora Brites,Yuri Persidsky,Servio H. Ramirez,Maria Alexandra Brito +11 more
TL;DR: Monolayers of HBMVECs show characteristically high transendothelial electric resistance and have proven useful in multiple functional studies for in vitro modeling of the human blood-brain barrier.
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Polyphenols journey through blood-brain barrier towards neuronal protection.
Inês Figueira,Gonçalo Garcia,Rui C. Pimpão,Ana Paula Terrasso,Inês Costa,A. F. Almeida,Lucélia Tavares,Teresa F. Pais,Paula Pinto,Paula Pinto,Maria Rita Ventura,Augusto Filipe,Gordon J. McDougall,Derek Stewart,Derek Stewart,Kwang S. Kim,Inês Palmela,Dora Brites,Maria Alexandra Brito,Catarina Brito,Cláudia N. Santos +20 more
TL;DR: The hypothesis that these small molecules, derived from dietary (poly)phenols may cross the BBB, reach brain cells, modulate microglia-mediated inflammation and exert neuroprotective effects, with potential for alleviation of neurodegenerative diseases is supported.