Maria Ankarcrona

TL;DR: It is reported that exposure of cortical neurons to relatively short durations or low concentrations of NMDA, S-nitrosocysteine, or 3-morpholinosydnonimine, which generate low levels of peroxynitrite, induces a delayed form of neurotoxicity predominated by apoptotic features.

TL;DR: It is shown that glutamate can induce either early necrosis or delayed apoptosis in cultures of cerebellar granule cells, suggesting that mitochondrial function is a critical factor that determines the mode of neuronal death in excitotoxicity.

TL;DR: This work presents a unique import mechanism for Aβ in mitochondria and demonstrates both in vitro and in vivo that Aβ is located to the mitochondrial cristae, and shows that extracellulary applied Aβ can be internalized by human neuroblastoma cells and can colocalize with mitochondrial markers.

TL;DR: Nitric oxide generation in response to a cytokine induced NO‐synthase or by NO donors stimulates the expression of the tumor suppressor gene, p53, in RAW 264.7 macrophages or pancreatic RINm5F cells prior to apoptosis.

TL;DR: A disturbance of polyamine biosynthesis occurred prior to cell growth or apoptosis elicited by oxidative stress, and effects as opposite as cell proliferation and deletion can be induced, in the same system, by varying the exposure to a prooxidant.