Author
Maria B. Carreira
Bio: Maria B. Carreira is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Nucleus accumbens & Dementia. The author has an hindex of 6, co-authored 15 publications receiving 219 citations.
Papers
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TL;DR: The findings reveal a molecular mechanism by which cocaine regulates HDAC5 function to antagonize the rewarding impact of cocaine, likely by putting a brake on drug-stimulated gene expression that supports drug-induced behavioral changes.
103 citations
TL;DR: It is found that dephosphorylated, nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (NAc) reduced cocaine reward-context associations and relapse-like behaviors in a cocaine self-administration model and that nuclear HDAC5 limits reinstatement of drug seeking independent of NPAS4.
82 citations
TL;DR: Results show that sex differences in fear behaviors following foreground contextual conditioning depend on the phase of the estrous cycle, and males expressed higher levels in all brain regions examined compared to females.
31 citations
TL;DR: In females anxiety- and depression-like behaviors explained a large part of the variance observed across tests in the authors' battery, whereas male behavior was primarily explained by variables related to locomotion.
15 citations
TL;DR: Depressive symptoms, limitations in Instrumental Activities of Daily Living, IL-7 and I-309 were significantly related to fall events, and could serve to guide public health professionals to establish clinical guidelines to reduce fall risks.
Abstract: Background: Falls are common among elderly adults, and are predictors of hospitalization, institutionalization and mortality.
Objective: The objective of the present study was to examine the relationship between blood-based markers of inflammation and fall events in a sample of elderly Hispanic adults.
Method: Data were collected from 190 participants enrolled in the Panama Aging Research Initiative study who completed baseline clinical and cognitive assessments. A non-fasting blood sample was obtained. Self-reported falls were classified as no falls, single falls or recurrent (two or more) falls reported in the 12 months prior to baseline evaluations. Serum levels of C Reactive Protein (CRP), T-lymphocyte secreting protein (I-309), interleukin 10 (IL-10), interleukin 6 (IL-6) and interleukin 7 (IL-7) were measured. Global cognition was assessed with the Mini Mental State Examination and depressive symptoms were assessed with the Geriatric Depression Scale (GDS-30). Multinomial logistic regression was used to assess the link between inflammation and fall events.
Results: Depressive symptoms, limitations in Instrumental Activities of Daily Living (IADL), IL-7 and I-309 were significantly related to fall events. Elevated levels of IL-7 increased the likelihood of single and recurrent falls, while increased levels of I-309 were associated only with recurrent falls. Greater IADL limitations and depressive symptoms were associated with an increased likelihood of recurrent falls.
Conclusion: There is a lack of research investigating the relationship between inflammatory biomarkers and fall events. These results provide evidence of risk factors for falls in Hispanic older adults, and could serve to guide public health professionals to establish clinical guidelines to reduce fall risks.
10 citations
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TL;DR: There is robust evidence that repeated exposure to drugs of abuse induces changes within the brain's reward regions in three major modes of epigenetic regulation-histone modifications such as acetylation and methylation, DNA methylation and non-coding RNAs.
317 citations
TL;DR: The latest advances in the field of epigenetic regulation are summarized, focusing on histone modifications, DNA methylation, and noncoding RNAs.
309 citations
TL;DR: The same mechanisms that establish the multi-wave temporal structure of gene induction also enable different gene sets to be induced by different activity durations and improve the understanding of activity-pattern-dependent synaptic plasticity.
245 citations
TL;DR: The anatomical-functional backdrop upon which several neuropeptides act within the NAc to modulate behavior is described, with a specific emphasis on nucleus accumbens medial shell and stress responsivity.
140 citations
TL;DR: This review brings up to date the knowledge of the physiological and pathological functions of class IIa HDACs, focusing in particular on the most recent discoveries from in vivo studies of mouse model systems.
Abstract: HDAC4, 5, 7 and 9 constitute the class IIa histone deacetylases (HDACs) within the large family of protein deacetylases. Class IIa HDACs have unique features that distinguish them from other HDACs. They contain an N-terminal domain that is required for their interaction with tissue-specific transcription factors and recruitment to their target genes. The N-terminal domain on class IIa HDACs also bears conserved serine residues that undergo signal-dependent phosphorylation, which brings about nuclear export of the enzymes and de-repression of their targets. One of the most important aspects of class IIa HDACs is their expression in specific tissues and organs within the organism, where they have crucial roles in development and differentiation processes. This review brings up to date our knowledge of the physiological and pathological functions of class IIa HDACs, focusing in particular on the most recent discoveries from in vivo studies of mouse model systems.
140 citations