Author
Maria Bruynseels
Bio: Maria Bruynseels is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Aryl & Isomerization. The author has an hindex of 4, co-authored 7 publications receiving 61 citations.
Topics: Aryl, Isomerization, Carbon-13 NMR, Structural isomer, Nitrile
Papers
More filters
••
TL;DR: In this article, the two structural isomers, 4 and 5, of 1-substituted-4-iminomethyl-1,2,3-triazoles are interconvertible when heated in dimethyl sulfoxide at 80°.
38 citations
••
TL;DR: In this article, 1-Amino-5-(substituted)amino-1,2,3-triazoles are directly produced by heating 1-aryl-5-chloro with hydrazine and 5-hydrazinotriazoles 2 are presumably formed first, but rearrange spontaneously under the reaction conditions.
Abstract: 1-Amino-5-(substituted)amino-1,2,3-triazoles (3) are directly produced by heating 1-aryl-5-chloro-1,2,3-triazoles (1) with hydrazine. The 5-hydrazinotriazoles 2 are presumably formed first, but rearrange spontaneously under the reaction conditions. The structures of the products were established principally on the basis of 13C NMR analyses.
10 citations
••
TL;DR: In this paper, 1-Phenyl-1,2,3-triazole-4-carbaldehyde is readily transformed into 1-alkyl- 1, 2, 3, 4, 5 carbaldehyde by thermal isomerization of the corresponding imines.
Abstract: 1-Phenyl-1,2,3-triazole-4-carbaldehyde is readily transformed into 1 -alkyl-1,2,3-triazole-4-carbalde-hydes by thermal isomerization of the corresponding imines, followed by acid hydrolysis.
9 citations
••
6 citations
••
TL;DR: In this paper, 1-Amino-5-(substituted)amino-1,2,3-triazoles are directly produced by heating 1-aryl-5-chloro with hydrazine and 5-hydrazinotriazoles 2 are presumably formed first, but rearrange spontaneously under the reaction conditions.
Abstract: 1-Amino-5-(substituted)amino-1,2,3-triazoles (3) are directly produced by heating 1-aryl-5-chloro-1,2,3-triazoles (1) with hydrazine. The 5-hydrazinotriazoles 2 are presumably formed first, but rearrange spontaneously under the reaction conditions. The structures of the products were established principally on the basis of 13C NMR analyses.
Cited by
More filters
••
TL;DR: In this paper, the synthetic routes to substituted 1,2,3-triazoles, including those containing functional groups, based on cyclisation of various nitrogen compounds published during the last 15 years are described.
Abstract: Data on the synthetic routes to substituted 1,2,3-triazoles, including those containing functional groups, based on cyclisation of various nitrogen compounds published during the last 15 years are described. Examples of using new triazole derivatives in agrochemistry, medicine and engineering are given.
197 citations
••
TL;DR: In this study, alpha-diazo-beta-oxoaldehyde compounds were condensed with different amines to yield 4-acyl-1H-1,2,3-triazole derivatives, which were investigated for their inhibition activities against tuberculosis.
103 citations
••
TL;DR: A series of novel 1,2,3-triazole substituted N-phenyl nitrone derivatives 5a-e and 6a-p exhibited significant inhibition of IL-1β secretion as a measure of anti-inflammatory activity against various cancer cell lines.
93 citations
••
TL;DR: In this paper, arylacetylene with an azide in hot water gave 1,4-disubstituted 1,2,3-triazoles in high yields, while similar reaction between a terminal aliphatic alkyne and an azides (except m-nitroazidobenzene) afforded a mixture of regioisomers with the ratio of 1, 4 to 1,5-isomers ranging from 3 : 1 to 28.6 : 1.
87 citations