María Cabello-Donayre

TL;DR: Evidence suggests that LABCG5 is involved in the salvage of the haem released after the breakdown of internalized haemoglobin, as Leishmania is auxotrophic for haem, and the pharmacological targeting of this route could represent a novel approach to control fatal visceral leishmaniasis.

TL;DR: Results show that trypanosomatid parasites rescue heme from endocytosed hemoglobin through endolysosomal HRG transporters, which could constitute novel drug targets.

TL;DR: Data is presented supporting a role for LmABCB3 in the biogenesis of cytosolic ISC, essential cofactors for cell viability in all three kingdoms of life and solid evidence suggesting that Lm ABCB3 is an essential gene is shown.

TL;DR: Promising antiparasitic activity and selectivity against control mammalian cells, together with their peculiar mechanism of action, render the carb-NDI conjugates as suitable candidates for the development of an innovative treatment of trypanosomiasis.

TL;DR: Results show that Leishmania parasites can rescue heme through plasma membrane transporter LFLVCRb, which could constitute a novel target for therapeutic intervention against Leishmaniasis and probably other trypanosomatid parasites in which FLVCR genes are also present.