Author
Maria Carla Gennaro
Other affiliations: University of Turin
Bio: Maria Carla Gennaro is an academic researcher from University of Eastern Piedmont. The author has contributed to research in topics: Sludge & Mass spectrometry. The author has an hindex of 30, co-authored 96 publications receiving 2759 citations. Previous affiliations of Maria Carla Gennaro include University of Turin.
Papers published on a yearly basis
Papers
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TL;DR: The review discusses the pitfalls of the matrix effect in mass spectrometry detection hyphenated to liquid chromatography separation and proposes hypotheses to explain the observed behaviours and proposes methods and strategies to overcome the matrix effects.
560 citations
TL;DR: Doping control analyses are generally performed in urine, a matrix that provides a prolonged detection time window, and less often in blood, serum, plasma, hair, saliva, and nails, and to identify the chemical structures of anabolic steroids the use of mass spectrometry detection is very advantageous.
115 citations
TL;DR: The whole methodology, comprehensive of the homogenization-extraction process and HPLC-MS/MS analysis, has been applied in the analysis of three typical Piedmont (North-West Italy) cheeses, known as Toma Piemontese, Raschera and Castelmagno.
102 citations
TL;DR: A new HPLC method, with UV and MS(n) detection, for the determination of seven pesticides, including the sulfonylurea herbicides amidosulfuron, azimsulfur, nicosulfuran, rimsulfuron), thifensulfuron methyl, tribenuronmethyl, and the fungicide azoxystrobin characterised by a methoxyacrilate structure is presented.
102 citations
TL;DR: In the whole, the results obtained for samples of river waters, blood serum, blood plasma, and fish confirm the ubiquitous presence of perfluorinated compounds, as recently denounced by many sources.
97 citations
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TL;DR: A review about the application of response surface methodology (RSM) in the optimization of analytical methods is presented and the theoretical principles and steps for its application are described to introduce readers to this multivariate statistical technique.
4,338 citations
2,730 citations
University of Graz1, Joanneum Research2, Research Institute of Molecular Pathology3, Institute of Molecular Biotechnology4, University of Natural Resources and Life Sciences, Vienna5, Foundation for Research & Technology – Hellas6, Austrian Academy of Sciences7, University of Salzburg8, University of Basel9, University of St Andrews10
TL;DR: This article showed that spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extended the lifespan of yeast, flies and worms, and human immune cells.
Abstract: Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events that cause programmed cell death. Here, we report that administration of spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extended the lifespan of yeast, flies and worms, and human immune cells. In addition, spermidine administration potently inhibited oxidative stress in ageing mice. In ageing yeast, spermidine treatment triggered epigenetic deacetylation of histone H3 through inhibition of histone acetyltransferases (HAT), suppressing oxidative stress and necrosis. Conversely, depletion of endogenous polyamines led to hyperacetylation, generation of reactive oxygen species, early necrotic death and decreased lifespan. The altered acetylation status of the chromatin led to significant upregulation of various autophagy-related transcripts, triggering autophagy in yeast, flies, worms and human cells. Finally, we found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity.
1,230 citations
University of Graz1, Joanneum Research2, Institute of Molecular Biotechnology3, Research Institute of Molecular Pathology4, University of Natural Resources and Life Sciences, Vienna5, Foundation for Research & Technology – Hellas6, Austrian Academy of Sciences7, University of Salzburg8, University of Basel9, University of St Andrews10
TL;DR: Administration of spermidine markedly extended the lifespan of yeast, flies and worms, and human immune cells and inhibited oxidative stress in ageing mice, and found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity.
Abstract: Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events that cause programmed cell death Here, we report that administration of spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extended the lifespan of yeast, flies and worms, and human immune cells In addition, spermidine administration potently inhibited oxidative stress in ageing mice In ageing yeast, spermidine treatment triggered epigenetic deacetylation of histone H3 through inhibition of histone acetyltransferases (HAT), suppressing oxidative stress and necrosis Conversely, depletion of endogenous polyamines led to hyperacetylation, generation of reactive oxygen species, early necrotic death and decreased lifespan The altered acetylation status of the chromatin led to significant upregulation of various autophagy-related transcripts, triggering autophagy in yeast, flies, worms and human cells Finally, we found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity
974 citations
TL;DR: In this paper, a detailed overview of dye pollution, dye classification and dye decolourization/degradation strategies is presented, focusing on the mechanisms involved in comparatively well understood TiO2 photocatalysts.
Abstract: The total annual production of synthetic dye is more than 7 × 105 tons. Annually, through only textile waste effluents, around one thousand tons of non-biodegradable textile dyes are discharged into natural streams and water bodies. Therefore, with growing environmental concerns and environmental awareness there is a need for the removal of dyes from local and industrial water effluents with a cost effective technology. In general, these dyes have been found to be resistant to biological as well as physical treatment technologies. In this regard, heterogeneous advanced oxidation processes (AOPs), involving photo-catalyzed degradation of dyes using semiconductor nanoparticles is considered as an efficient cure for dye pollution. In the last two decades TiO2 has received considerable interest because of its high potential as a photocatalyst to degrade a wide range of organic material including dyes. This review starts with (i) a brief overview on dye pollution, dye classification and dye decolourization/degradation strategies; (ii) focuses on the mechanisms involved in comparatively well understood TiO2 photocatalysts and (iii) discusses recent advancements to enhance TiO2 photocatalytic efficiency by (a) doping with metals, non-metals, transition metals, noble metals and lanthanide ions, (b) structural modifications of TiO2 and (c) immobilization of TiO2 by using various supports to make it a flexible and cost-effective commercial dye treatment technology.
911 citations