Maria Eugenia Caligiuri

TL;DR: In the largest neuroimaging study to date, Whelan and colleagues report robust structural alterations across and within epilepsy syndromes, including shared volume loss in the thalamus, and widespread cortical thickness differences.

TL;DR: It is concluded that, in order to avoid artifacts and exclude the several sources of bias that may influence the analysis, an optimal method should comprise a careful preprocessing of the images, be based on multimodal, complementary data, take into account spatial information about the lesions and correct for false positives.

TL;DR: Overall, patients with epilepsy showed white matter abnormalities in the corpus callosum, cingulum and external capsule, with differing severity across epilepsy syndromes, and microstructural abnormalities across major association, commissural, and projection fibres in a large multicentre study of epilepsy are demonstrated.

TL;DR: This cross-sectional mega-analysis integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in adults with epilepsy and healthy controls and provided deeper insights into the macroscale features that shape the pathophysiology of common epilepsies.

TL;DR: The best quantitative predictors in several brain regions were iron deposition and microstructural damage, rather than macroscopic tissue atrophy, suggesting that multiple predictors better capture age-induced tissue alterations.