M
Maria G. Salazar
Researcher at University of Alabama at Birmingham
Publications - 28
Citations - 8411
Maria G. Salazar is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 20, co-authored 26 publications receiving 7936 citations. Previous affiliations of Maria G. Salazar include University of Alabama & University of London.
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Journal ArticleDOI
Antibody neutralization and escape by HIV-1
Xiping Wei,Julie M. Decker,Shuyi Wang,Huxiong Hui,John C. Kappes,Xiaoyun Wu,Jesus F. Salazar-Gonzalez,Maria G. Salazar,J. Michael Kilby,Michael S. Saag,Natalia L. Komarova,Martin A. Nowak,Beatrice H. Hahn,Peter D. Kwong,George M. Shaw +14 more
TL;DR: The detection of autologous Nab as early as 52 days after detection of HIV-specific antibodies is reported, indicating a new mechanism contributing to HIV-1 persistence in the face of an evolving antibody repertoire.
Journal ArticleDOI
Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
Brandon F. Keele,Elena E. Giorgi,Elena E. Giorgi,Jesus F. Salazar-Gonzalez,Julie M. Decker,Kimmy T. Pham,Maria G. Salazar,Chuanxi Sun,Truman Grayson,Shuyi Wang,Hui Li,Xiping Wei,Chunlai Jiang,Jennifer L. Kirchherr,Feng Gao,Jeffery A. Anderson,Li Hua Ping,Ronald Swanstrom,Georgia D. Tomaras,William A. Blattner,Paul A. Goepfert,J. Michael Kilby,Michael S. Saag,Eric Delwart,Michael P. Busch,Myron S. Cohen,David C. Montefiori,Barton F. Haynes,Brian Gaschen,Gayathri Athreya,Ha Y. Lee,Natasha T. Wood,Cathal Seoighe,Alan S. Perelson,Tanmoy Bhattacharya,Tanmoy Bhattacharya,Bette T. Korber,Bette T. Korber,Beatrice H. Hahn,George M. Shaw +39 more
TL;DR: A mathematical model of random viral evolution and phylogenetic tree construction is developed and used to analyze 3,449 complete env sequences derived by single genome amplification from 102 subjects with acute HIV-1 (clade B) infection, suggesting a finite window of potential vulnerability of HIV- 1 to vaccine-elicited immune responses, although phenotypic properties of transmitted Envs pose a formidable defense.
Journal ArticleDOI
Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection.
Jesus F. Salazar-Gonzalez,Maria G. Salazar,Brandon F. Keele,Gerald H. Learn,Elena E. Giorgi,Elena E. Giorgi,Hui Li,Julie M. Decker,Shuyi Wang,Joshua Baalwa,Matthias H. Kraus,Nicholas F. Parrish,Katharina S. Shaw,M. Brad Guffey,Katharine J. Bar,Katie L. Davis,Christina Ochsenbauer-Jambor,John C. Kappes,Michael S. Saag,Myron S. Cohen,Joseph Mulenga,Cynthia A. Derdeyn,Susan Allen,Eric Hunter,Martin Markowitz,Martin Markowitz,Peter T. Hraber,Alan S. Perelson,Tanmoy Bhattacharya,Tanmoy Bhattacharya,Barton F. Haynes,Bette T. Korber,Bette T. Korber,Beatrice H. Hahn,George M. Shaw +34 more
TL;DR: Viral properties associated with mucosal HIV-1 transmission and a limited set of rapidly evolving adaptive mutations driven primarily, but not exclusively, by early cytotoxic T cell responses are revealed.
Journal ArticleDOI
The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
Nilu Goonetilleke,Michael K. P. Liu,Jesus F. Salazar-Gonzalez,Guido Ferrari,Elena E. Giorgi,Vitaly V. Ganusov,Brandon F. Keele,Gerald H. Learn,Emma L. Turnbull,Maria G. Salazar,Kent J. Weinhold,Stephen Moore,Norman L. Letvin,Barton F. Haynes,Myron S. Cohen,Peter T. Hraber,Tanmoy Bhattacharya,Tanmoy Bhattacharya,Persephone Borrow,Alan S. Perelson,Beatrice H. Hahn,George M. Shaw,Bette T. Korber,Bette T. Korber,Andrew J. McMichael +24 more
TL;DR: Kinetic analysis and mathematical modeling of virus immune escape showed that the contribution of CD8 T cell–mediated killing of productively infected cells was earlier and much greater than previously recognized and that it contributed to the initial decline of plasma virus in acute infection.
Journal ArticleDOI
Deciphering Human Immunodeficiency Virus Type 1 Transmission and Early Envelope Diversification by Single-Genome Amplification and Sequencing
Jesus F. Salazar-Gonzalez,Elizabeth Bailes,Kimmy T. Pham,Maria G. Salazar,M. Brad Guffey,Brandon F. Keele,Cynthia A. Derdeyn,Paul Farmer,Eric Hunter,Susan Allen,Olivier Manigart,Joseph Mulenga,Jeffrey A. Anderson,Ronald Swanstrom,Barton F. Haynes,Gayathri Athreya,Bette T. Korber,Paul M. Sharp,George M. Shaw,Beatrice H. Hahn +19 more
TL;DR: It is shown that HIV-1 env genes, other viral genes, and even full-length viral genomes responsible for productive clinical infection can be identified by SGA analysis of plasma virus sampled at intervals typical in large-scale vaccine trials and that pathways of viral diversification and immune escape can be determined accurately.