M
Maria Isabel D. Rossi
Researcher at Federal University of Rio de Janeiro
Publications - 36
Citations - 2593
Maria Isabel D. Rossi is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Stromal cell & Mesenchymal stem cell. The author has an hindex of 15, co-authored 35 publications receiving 2423 citations. Previous affiliations of Maria Isabel D. Rossi include The Texas Heart Institute & Federal Fluminense University.
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Journal ArticleDOI
Transendocardial, Autologous Bone Marrow Cell Transplantation for Severe, Chronic Ischemic Heart Failure
Emerson C. Perin,Hans F. Dohmann,Radovan Borojevic,Suzana A. Silva,Andre L.S. Sousa,Claudio Tinoco Mesquita,Maria Isabel D. Rossi,Antonio Carlos Carvalho,Hélio S. Dutra,Hans J.F. Dohmann,Guilherme V. Silva,Luciano Belem,Ricardo Vivacqua,Fernando Oswaldo Dias Rangel,Roberto Esporcatte,Yong-Jian Geng,William K. Vaughn,Joao A.R. Assad,Evandro Tinoco Mesquita,James T. Willerson +19 more
TL;DR: The present study demonstrates the relative safety of intramyocardial injections of bone marrow–derived stem cells in humans with severe heart failure and the potential for improving myocardial blood flow with associated enhancement of regional and global left ventricular function.
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Improved Exercise Capacity and Ischemia 6 and 12 Months After Transendocardial Injection of Autologous Bone Marrow Mononuclear Cells for Ischemic Cardiomyopathy
Emerson C. Perin,Hans F. Dohmann,Radovan Borojevic,Suzana A. Silva,Andre L.S. Sousa,Guilherme V. Silva,Claudio Tinoco Mesquita,Luciano Belem,William K. Vaughn,Fernando Oswaldo Dias Rangel,Joao A.R. Assad,Antonio Carlos Carvalho,Rodrigo Branco,Maria Isabel D. Rossi,Hans J.F. Dohmann,James T. Willerson +15 more
TL;DR: The 6- and 12-month follow-up data suggest that transendocardial injection of ABMMNCs in patients with end-stage ischemic heart disease may produce a durable therapeutic effect and improve myocardial perfusion and exercise capacity.
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Intraperitoneal but Not Intravenous Cryopreserved Mesenchymal Stromal Cells Home to the Inflamed Colon and Ameliorate Experimental Colitis
Morgana T. Castelo-Branco,Igor D. P. Soares,Daiana V. Lopes,Fernanda Buongusto,Cesonia A. Martinusso,Alyson do Rosario,Sergio Augusto Lopes de Souza,Bianca Gutfilen,Lea Mirian Barbosa da Fonseca,Celeste C. Elia,Kalil Madi,Alberto Schanaider,Maria Isabel D. Rossi,Heitor Siffert Pereira de Souza +13 more
TL;DR: Intraperitoneal injection of cryopreserved subcutaneous adipose tissue and bone marrow-derived mesenchymal stromal cells reduced the endoscopic and histopathologic severity of colitis, the collagen deposition, and the epithelial apoptosis.
Journal ArticleDOI
Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model.
Ana Paula D. N. de Barros,Christina Maeda Takiya,Luciana Ribeiro Garzoni,Mona Lisa Leal-Ferreira,Hélio S. Dutra,Luciana B. Chiarini,Maria de Nazareth Leal de Meirelles,Radovan Borojevic,Maria Isabel D. Rossi +8 more
TL;DR: Undifferentiated and one-week osteo-induced BMSC self-assembled in a 3D spheroid and formed a microenvironment that is informative for hematopoietic progenitor cells, allowing their lodgment and controlling their proliferation.
Journal ArticleDOI
Neutrophil Extracellular Traps (NETs) Promote Pro-Metastatic Phenotype in Human Breast Cancer Cells through Epithelial–Mesenchymal Transition
Karina Martins-Cardoso,Vitor H. Almeida,Kayo Moreira Bagri,Maria Isabel D. Rossi,Claudia Mermelstein,Sandra König,Robson Q. Monteiro +6 more
TL;DR: Nets drive pro-metastatic phenotype in human breast cancer cells through the activation of the EMT program, andalyses of TCGA data showed that samples from breast cancer patients exhibit a significant correlation between pro-tumoral and neutrophil signature gene expression, including several EMT and pro- metastatic factors.