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Maria J. Sarmento

Researcher at Academy of Sciences of the Czech Republic

Publications -  17
Citations -  379

Maria J. Sarmento is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Membrane & Lipid bilayer. The author has an hindex of 8, co-authored 15 publications receiving 258 citations. Previous affiliations of Maria J. Sarmento include Instituto Superior Técnico & Istituto Italiano di Tecnologia.

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Journal ArticleDOI

Membrane Lipid Nanodomains.

TL;DR: This review summarizes the knowledge on lipid nanodomains in model membranes and exposes how their specific character contrasts with large-scale phase separation and the effects of curvature, asymmetry, and ions on membrane nanadomains are shown to be highly relevant aspects that may also modulate lipid nanadoms in cellular membranes.
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Ca(2+) induces PI(4,5)P2 clusters on lipid bilayers at physiological PI(4,5)P2 and Ca(2+) concentrations.

TL;DR: It is shown that Ca(2+) promotes PI(4,5)P2 clustering in lipid bilayers at physiological concentrations of both Ca( 2+) and PI( 4,5), and calcium mediated PI(3,3)P3 clustering was more pronounced in liquid ordered (lo) membranes, and the PI(2,3-Ca(2)+ clusters presented an increased affinity for lo domains.
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Reorganization of lipid domain distribution in giant unilamellar vesicles upon immobilization with different membrane tethers.

TL;DR: It is concluded that tethering of lipid membranes to protein surfaces has the potential to drastically reorganize the distribution of lipid domains, and this reorganization is solely dictated by the partition properties of the protein-tether complex.
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Exploiting the tunability of stimulated emission depletion microscopy for super-resolution imaging of nuclear structures

TL;DR: A method to enhance the spatial resolution of a stimulated-emission depletion (STED) microscope based only on the modulation of the STED intensity during the acquisition of a STED image is presented and it is shown that modulating STEDintensity during acquisition results in an enhanced resolution and reduced background.
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Interleaflet Coupling of Lipid Nanodomains - Insights From in vitro Systems.

TL;DR: In this review, current theoretical and experimental knowledge that led to the current view that domains are – irrespective of their size – commonly registered across the bilayer are summarized.