Maria Kogadeeva

TL;DR: Elevating L-arginine levels induced global metabolic changes including a shift from glycolysis to oxidative phosphorylation in activated T cells and promoted the generation of central memory-like cells endowed with higher survival capacity and, in a mouse model, anti-tumor activity.

TL;DR: Global absolute protein measurements provide a quantitative description of microbial states, which can support the development of therapeutic interventions and allow protein alterations to be translated into changes in maximal enzymatic reaction velocities, enhancing understanding of metabolic adaptations.

TL;DR: The role of phosphorylation in controlling the metabolic flux realised by these three enzymes is demonstrated through absolute peptide quantification by targeted mass spectrometry, metabolomics and physiological flux analysis in mutants with genetically removed phosphosites.

TL;DR: A potentially crucial role for small, ‘non-enzymatic’ peptides in metabolism take-over is suggested and on potential biotechnical applications for such peptides are hypothesized.

TL;DR: An experimentally accessible model for early infection of human macrophages by Mycobacterium tuberculosis, the etiological agent of tuberculosis, is exploited to study host-pathogen interactions with a multi-omics approach to better understand the intracellular lifestyle of pathogens and their metabolic robustness and resistance to metabolic interventions.