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Maria M. M. Santos

Bio: Maria M. M. Santos is an academic researcher from University of Lisbon. The author has contributed to research in topics: MDMX & Malaria. The author has an hindex of 23, co-authored 81 publications receiving 1801 citations. Previous affiliations of Maria M. M. Santos include Universidade Federal Rural do Rio de Janeiro & University of Barcelona.
Topics: MDMX, Malaria, NMDA receptor, Cancer, Small molecule


Papers
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Journal ArticleDOI
TL;DR: In this article, a questionnaire was sent out to a large sample of small and medium-sized enterprises (SMEs) in Portugal to identify accurately and extensively: CSR practices at the social, economic and environmental levels; the motivations, perceived benefits, existing obstacles; and the types of support and strategies that render possible an explanation of the factors which place the greatest restrictions on SME adoption of CSR practice.
Abstract: Purpose – Given the greater recognition of the role played by small and medium‐sized enterprises (SMEs) within the European economy, this research aims to provide an insight into SME CSR practices. Within this scope, the objective is to identify accurately and extensively: CSR practices at the social, economic and environmental levels; the motivations, perceived benefits, existing obstacles; and the types of support and strategies that render possible an explanation of the factors which place the greatest restrictions on SME adoption of CSR practices.Design/methodology/approach – This research was realized through the completion of a questionnaire type inquiry structured around table‐based analysis. The questionnaire was sent out to a large sample of SMEs in Portugal.Findings – The main results demonstrate that, while CSR takes on an informal, non‐structured character, it has been incorporated into the daily management of such companies. Furthermore, contrary to what happens at large companies, CSR at SME...

177 citations

Journal ArticleDOI
TL;DR: This review emphasizes on the new developments from literature reports on Michael acceptors as potential cysteine protease inhibitors, namely vinyl sulfones, alpha,beta-unsaturated carbonyl derivatives and aza-peptides.
Abstract: Cysteine proteases selectively catalyze the hydrolysis of peptide bonds. Uncontrolled, unregulated, or undesired proteolysis can lead to many disease states including emphysema, stroke, viral infections, cancer, Alzheimer's disease, inflammation, and arthritis. Cysteine proteases inhibitors thus have considerable potential utility for therapeutic intervention in a variety of disease states. This review emphasizes on the new developments from literature reports on Michael acceptors as potential cysteine protease inhibitors, namely vinyl sulfones, alpha,beta-unsaturated carbonyl derivatives and aza-peptides. These compounds irreversibly alkylate the active site cysteine residue via conjugate addition. Examples of Michael acceptors inhibitors that have already progressed to clinical testing are also presented.

137 citations

Journal ArticleDOI
TL;DR: The results suggest that the naphtho[2,3-d]isoxazole-4,9-dione scaffold has the potential to be developed into novel and safe therapeutic antifungal agents.

93 citations

Journal ArticleDOI
TL;DR: Two spiropyrazoline oxindoles were highly selective between MCF-7 tumor cells and MDA-MB-231 tumor cells, and were noncytotoxic against HEK 293T non tumor derived cell lines.

77 citations


Cited by
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01 Jan 1999
TL;DR: Caspases, a family of cysteine-dependent aspartate-directed proteases, are prominent among the death proteases as discussed by the authors, and they play critical roles in initiation and execution of this process.
Abstract: ■ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death that can be triggered by a variety of physiological and pathological stimuli. Studies performed over the past 10 years have demonstrated that proteases play critical roles in initiation and execution of this process. The caspases, a family of cysteine-dependent aspartate-directed proteases, are prominent among the death proteases. Caspases are synthesized as relatively inactive zymogens that become activated by scaffold-mediated transactivation or by cleavage via upstream proteases in an intracellular cascade. Regulation of caspase activation and activity occurs at several different levels: ( a) Zymogen gene transcription is regulated; ( b) antiapoptotic members of the Bcl-2 family and other cellular polypeptides block proximity-induced activation of certain procaspases; and ( c) certain cellular inhibitor of apoptosis proteins (cIAPs) can bind to and inhibit active caspases. Once activated, caspases cleave a variety of intracellular polypeptides, including major structural elements of the cytoplasm and nucleus, components of the DNA repair machinery, and a number of protein kinases. Collectively, these scissions disrupt survival pathways and disassemble important architectural components of the cell, contributing to the stereotypic morphological and biochemical changes that characterize apoptotic cell death.

2,685 citations

01 Feb 1995
TL;DR: In this paper, the unpolarized absorption and circular dichroism spectra of the fundamental vibrational transitions of the chiral molecule, 4-methyl-2-oxetanone, are calculated ab initio using DFT, MP2, and SCF methodologies and a 5S4P2D/3S2P (TZ2P) basis set.
Abstract: : The unpolarized absorption and circular dichroism spectra of the fundamental vibrational transitions of the chiral molecule, 4-methyl-2-oxetanone, are calculated ab initio. Harmonic force fields are obtained using Density Functional Theory (DFT), MP2, and SCF methodologies and a 5S4P2D/3S2P (TZ2P) basis set. DFT calculations use the Local Spin Density Approximation (LSDA), BLYP, and Becke3LYP (B3LYP) density functionals. Mid-IR spectra predicted using LSDA, BLYP, and B3LYP force fields are of significantly different quality, the B3LYP force field yielding spectra in clearly superior, and overall excellent, agreement with experiment. The MP2 force field yields spectra in slightly worse agreement with experiment than the B3LYP force field. The SCF force field yields spectra in poor agreement with experiment.The basis set dependence of B3LYP force fields is also explored: the 6-31G* and TZ2P basis sets give very similar results while the 3-21G basis set yields spectra in substantially worse agreements with experiment. jg

1,652 citations