Maria Pia Protti

TL;DR: It is demonstrated that pocket profiles are nearly independent of the remaining HLA-DR cleft, and this approach has implications for the development of epitope-based vaccines.

TL;DR: Expression of TSLP in pancreatic cancer correlates with Th2 deviation of antitumor immunity that is associated with decrease of patient survival.

TL;DR: It is shown that injection of apoptotic RMA cells, a syngeneic T cell lymphoma, into C57BL/6 mice results in priming of a functional and long-lasting tumor-specific immune response, and the different roles of Mphi and DCs in the physiologic clearance of unwanted cells are outlined and have implications in designing immunomodulating vaccines.

TL;DR: Cold target inhibition experiments demonstrated indeed that the CD4+ T cells recognized MAGE-3281–295 in association with HLA-DR11 on melanoma cells, the first evidence that a tumor-specific shared antigen forms CD4+, opening the possibility of wide application to other tumor-associated antigens.

TL;DR: The indirect presentation of epitopes from engulfed apoptotic cells by scavenger Ag-presenting phagocytes may, in the absence of "danger" signals, have implications for the establishment of central and peripheral self-tolerance.