M
Maria Shipkova
Researcher at Synlab Group
Publications - 127
Citations - 6211
Maria Shipkova is an academic researcher from Synlab Group. The author has contributed to research in topics: Mycophenolic acid & Transplantation. The author has an hindex of 41, co-authored 124 publications receiving 5555 citations. Previous affiliations of Maria Shipkova include University of Göttingen & Sofia Medical University.
Papers
More filters
Journal ArticleDOI
Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy : Second Consensus Report
Mercè Brunet,Teun van Gelder,Anders Åsberg,Vincent Haufroid,Vincent Haufroid,Dennis A. Hesselink,Loralie J. Langman,Florian Lemaitre,Pierre Marquet,Christoph Seger,Maria Shipkova,Alexander A. Vinks,Alexander A. Vinks,Pierre Wallemacq,Eberhard Wieland,Jean-Baptiste Woillard,Markus J. Barten,Klemens Budde,Helena Colom,Maja Theresa Dieterlen,Laure Elens,Kamisha L. Johnson-Davis,Paweł K. Kunicki,Iain MacPhee,Satohiro Masuda,Binu S. Mathew,Olga Millán,Tomoyuki Mizuno,Tomoyuki Mizuno,Dirk Jan A.R. Moes,Caroline Monchaud,Ofelia Noceti,Tomasz Pawinski,Nicolas Picard,Ron H.N. van Schaik,Claudia Sommerer,Nils Tore Vethe,Brenda C. M. de Winter,Uwe Christians,Stein Bergan +39 more
TL;DR: It is concluded that considerable advances in the different fields of tacrolimus monitoring have been achieved during this last decade, and the Expert Committee concludes that Continued efforts should focus on the opportunities to implement in clinical routine the combination of new standardized PK approaches with PG, and valid biomarkers to further personalize tacolimus therapy and to improve long-term outcomes for treated patients.
Journal ArticleDOI
The Pharmacokinetic-Pharmacodynamic Relationship for Total and Free Mycophenolic Acid in Pediatric Renal Transplant Recipients: A Report of the German Study Group on Mycophenolate Mofetil Therapy
Lutz T. Weber,Maria Shipkova,Victor W. Armstrong,Natalie Wagner,Ekkehard Schütz,Otto Mehls,Lothar Bernd Zimmerhackl,Michael Oellerich,Burkhard Tönshoff +8 more
TL;DR: Investigation of the pharmacokinetic (PK)/pharmacodynamic relationship of total and free MPA and PK values for the assessment of an individual's MPA PK parameters indicates that therapeutic drug monitoring of MPA has the potential for optimization of MMF efficacy in this patient population by steering patients away from the low values of M PA PK variables that are associated with an increased rejection risk.
Journal ArticleDOI
Acyl glucuronide drug metabolites: toxicological and analytical implications.
TL;DR: This review summarizes the most recent evidence concerning biologic and toxicologic effects of acyl glucuronide metabolites of various drugs and discusses their relevance for drug monitoring.
Journal ArticleDOI
Pharmacokinetics of mycophenolic acid (MPA) and determinants of MPA free fraction in pediatric and adult renal transplant recipients. German Study group on Mycophenolate Mofetil Therapy in Pediatric Renal Transplant Recipients.
Lutz T. Weber,Maria Shipkova,T Lamersdorf,Paul Dieter Niedmann,Manfred Wiesel,A. Mandelbaum,Lothar Bernd Zimmerhackl,Ekkehard Schütz,Otto Mehls,Michael Oellerich,Victor W. Armstrong,Burkhard Tönshoff +11 more
TL;DR: Comparing the pharmacokinetics of MPA and its major metabolite MPA glucuronide in pediatric renal transplant recipients receiving 600 mg MMF/m2 body surface area twice a day to those of adults on the currently recommended oral dose of 1 g of MMF once a day is compared.
Journal ArticleDOI
Identification of glucoside and carboxyl-linked glucuronide conjugates of mycophenolic acid in plasma of transplant recipients treated with mycophenolate mofetil
Maria Shipkova,Victor W. Armstrong,Eberhard Wieland,Paul Dieter Niedmann,Ekkehard Schütz,Gerald Brenner-Weiß,Martin Voihsel,Felix Braun,Michael Oellerich +8 more
TL;DR: Results suggest that M‐1 is the 7‐OH glucose conjugate of MPA; M‐2 is the acyl glucuronide conjugates of M PA; and M‐3 is derived from the hepatic CYP450 system.