Maria Tretiakova

TL;DR: This study validates the "breast tumor intrinsic" subtype classification as an objective means of tumor classification that should be translated into a clinical assay for further retrospective and prospective validation.

TL;DR: The histologic and immunophenotypic properties of breast basal-like carcinomas that were first positively identified using DNA microarray analysis are characterized to assist in the identification of basal- like carcinomas in clinical specimens, facilitating treatment and epidemiologic studies of this tumor subtype.

TL;DR: The results suggest that lack of critical chemokines in a subset of melanoma metastases may limit the migration of activated T cells, which in turn could limit the effectiveness of antitumor immunity.

TL;DR: It is shown that, under conditions of dysregulated IL15 expression in vivo in patients with celiac disease and in vitro in healthy individuals, multiple steps of the NKG2D/DAP10 signaling pathway leading to ERK and JNK activation are coordinately primed to activate direct cytolytic function independent of TCR specificity in effector CD8 T cells.

TL;DR: First direct evidence by small interfering RNA targeting and small molecule inhibitor that c-Met is important in NSCLC biology and biochemistry is provided.