M
Mariagrazia Grilli
Researcher at University of Eastern Piedmont
Publications - 97
Citations - 6026
Mariagrazia Grilli is an academic researcher from University of Eastern Piedmont. The author has contributed to research in topics: Neurogenesis & Hippocampal formation. The author has an hindex of 30, co-authored 94 publications receiving 5648 citations. Previous affiliations of Mariagrazia Grilli include National Institutes of Health & Merck & Co..
Papers
More filters
Journal ArticleDOI
Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695
M. Azhar Chishti,Dun-Shen Yang,Christopher Janus,Amie L. Phinney,Patrick Horne,Jacqueline Pearson,Robert Strome,Noah Zuker,James E. Loukides,Janet French,Sherry Turner,Gianluca Lozza,Mariagrazia Grilli,Suzanne Kunicki,Céline Morissette,Julie Paquette,Francine Gervais,Catherine Bergeron,Paul E. Fraser,George A. Carlson,Peter St George-Hyslop,David Westaway +21 more
TL;DR: High level production of the pathogenic Aβ42 form of Aβ peptide was associated with an early impairment in TgCRND8 mice in acquisition and learning reversal in the reference memory version of the Morris water maze, present by 3 months of age.
Book ChapterDOI
NF-kappa B and Rel: participants in a multiform transcriptional regulatory system.
TL;DR: This chapter highlights NF-кB/Rel protein complex, a family of dimer-forming proteins with homology to the rel oncogene that has the important ability to carry signals from the cytoplasm into the nucleus and trans -activate specific genes by binding directly to their promoters.
Journal ArticleDOI
Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation
TL;DR: At concentrations compatible with amounts in plasma during chronic anti-inflammatory therapy, acetylsalicylic acid and its metabolite sodium salicylate were found to be protective against neurotoxicity elicited by the excitatory amino acid glutamate in rat primary neuronal cultures and hippocampal slices.
Journal ArticleDOI
NF-kappa B subunit regulation in nontransformed CD4+ T lymphocytes.
TL;DR: Regulation of interleukin-2 (IL-2) gene expression by the p50 and p65 subunits of the DNA binding protein NF-kappa B was studied in nontransformed CD4+ T lymphocyte clones and the switch from p50-p50 to p65-p65 complexes depended on a protein that caused sequestration of the p60- p50 complex in the nucleus.
Journal ArticleDOI
Interleukin-10 modulates neuronal threshold of vulnerability to ischaemic damage.
Mariagrazia Grilli,Ilaria Barbieri,Harsha Basudev,Rossella Brusa,C. Casati,Gianluca Lozza,Ennio Ongini +6 more
TL;DR: A potential neuroprotective role of IL‐10 against cerebral ischaemia when administered exogenously or made available from endogenous sources is suggested.