Mariana F. Wolfner

Bio: Mariana F. Wolfner is an academic researcher from Cornell University. The author has contributed to research in topics: Drosophila melanogaster & Sperm. The author has an hindex of 74, co-authored 236 publications receiving 19345 citations. Previous affiliations of Mariana F. Wolfner include University of California, San Diego & Carnegie Institution for Science.

Evolution of genes and genomes on the Drosophila phylogeny.

Abstract: Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.

Cost of mating in Drosophila melanogaster females is mediated by male accessory gland products

Abstract: Female Drosophila melanogaster with environmentally or genetically elevated rates of mating die younger than controls. This cost of mating is not attributable to receipt of sperm. We demonstrate here that seminal fluid products from the main cells of the male accessory gland are responsible for the cost of mating in females, and that increasing exposure to these products increases female death rate. Main-cell products are also involved in elevating the rate of female egg-laying, in reducing female receptivity to further matings and in removing or destroying sperm of previous mates. The cost of mating to females may therefore represent a side-effect of evolutionary conflict between males.

Insect seminal fluid proteins: identification and function.

Abstract: Seminal fluid proteins (SFPs) produced in reproductive tract tissues of male insects and transferred to females during mating induce numerous physiological and behavioral postmating changes in females. These changes include decreasing receptivity to remating; affecting sperm storage parameters; increasing egg production; and modulating sperm competition, feeding behaviors, and mating plug formation. In addition, SFPs also have antimicrobial functions and induce expression of antimicrobial peptides in at least some insects. Here, we review recent identification of insect SFPs and discuss the multiple roles these proteins play in the postmating processes of female insects.

The sex peptide of Drosophila melanogaster: female post-mating responses analyzed by using RNA interference.

Abstract: Mating induces profound changes in female insect behavior and physiology In Drosophila melanogaster, mating causes a reduction in sexual receptivity and an elevation in egg production for at least 5 days Injection of the seminal fluid sex peptide (SP) induces both responses in virgin females, but only for 1–2 days The role of SP in eliciting the responses to mating remains to be elucidated Functional redundancy between seminal fluid components may occur In addition, mating with spermless males results in brief (1- to 2-day) post-mating responses, indicating either that there is a “sperm effect” or that sperm act as carriers for SP or other seminal fluid components Here we used RNA interference to suppress SP expression, to determine whether SP is required to elicit full post-mating responses, the magnitude of responses due to other seminal fluid components, and whether SP accounts for the “sperm effect” Receptivity was higher and egg production lower in females mated to SP knock-down males than in controls Comparison with virgins showed that the responses were brief SP is therefore required for normal magnitude and persistence of postmating responses Sperm transfer and use were normal in mates of SP knock-down males, yet their post-mating responses were briefer than after normal matings, and similar to those reported in mates of spermless son-of-tudor males The prolonged “sperm effect” on female receptivity and egg production is therefore entirely attributable to SP, but sperm are necessary for its occurrence

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The heat-shock proteins

Abstract: Roles moleculaires des proteines de choc thermique dans le fonctionnement des organismes a des temperatures normales et suite a des chocs thermiques; differents genes impliques

“Bioinformatics” 특집을 내면서

Abstract: BIOE 402. Medical Technology Assessment. 2 or 3 hours. Bioentrepreneur course. Assessment of medical technology in the context of commercialization. Objectives, competition, market share, funding, pricing, manufacturing, growth, and intellectual property; many issues unique to biomedical products. Course Information: 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.

Bayesian inference of phylogeny and its impact on evolutionary biology

Abstract: As a discipline, phylogenetics is becoming transformed by a flood of molecular data. These data allow broad questions to be asked about the history of life, but also present difficult statistical and computational problems. Bayesian inference of phylogeny brings a new perspective to a number of outstanding issues in evolutionary biology, including the analysis of large phylogenetic trees and complex evolutionary models and the detection of the footprint of natural selection in DNA sequences.