M
Mariana Lagos-Quintana
Researcher at Max Planck Society
Publications - 18
Citations - 13279
Mariana Lagos-Quintana is an academic researcher from Max Planck Society. The author has contributed to research in topics: RNA & microRNA. The author has an hindex of 11, co-authored 18 publications receiving 12609 citations. Previous affiliations of Mariana Lagos-Quintana include Rockefeller University & Howard Hughes Medical Institute.
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Journal ArticleDOI
Identification of novel genes coding for small expressed RNAs.
TL;DR: It is shown that many 21- and 22-nt expressed RNAs, termed microRNAs, exist in invertebrates and vertebrates and that some of these novel RNAs are highly conserved, which suggests that sequence-specific, posttranscriptional regulatory mechanisms mediated by smallRNAs are more general than previously appreciated.
Journal ArticleDOI
Identification of tissue-specific microRNAs from mouse
Mariana Lagos-Quintana,Reinhard Rauhut,Abdullah Yalcin,Jutta Meyer,Winfried Lendeckel,Thomas Tuschl +5 more
TL;DR: 34 novel miRNAs were identified by tissue-specific cloning of approximately 21-nucleotide RNAs from mouse and a miRNA was identified that appears to be the fruitfly and mammalian ortholog of C. elegans lin-4 stRNA.
Journal ArticleDOI
A novel class of small RNAs bind to MILI protein in mouse testes
Alexei A. Aravin,Dimos Gaidatzis,Sébastien Pfeffer,Sébastien Pfeffer,Sébastien Pfeffer,Mariana Lagos-Quintana,Pablo Landgraf,Nicola Iovino,Patricia L. Morris,Michael J. Brownstein,Satomi Kuramochi-Miyagawa,Toru Nakano,Minchen Chien,James J. Russo,Jingyue Ju,Robert L. Sheridan,Chris Sander,Mihaela Zavolan,Thomas Tuschl +18 more
TL;DR: A new class of small RNAs that bind to MILI in mouse male germ cells, where they accumulate at the onset of meiosis are described, and are referred to as ‘Piwi-interacting RNAs’ or piRNAs.
Journal ArticleDOI
Identification of microRNAs of the herpesvirus family
Sébastien Pfeffer,Alain Sewer,Mariana Lagos-Quintana,Robert L. Sheridan,Chris Sander,Friedrich A. Grässer,Linda F. van Dyk,C. Kiong Ho,C. Kiong Ho,Stewart Shuman,Minchen Chien,James J. Russo,Jingyue Ju,Glenn Randall,Brett D. Lindenbach,Charles M. Rice,Viviana Simon,David D. Ho,Mihaela Zavolan,Thomas Tuschl +19 more
TL;DR: To identify other miRNA genes in pathogenic viruses, a new miRNA gene prediction method with small-RNA cloning from several virus-infected cell types was combined and predicted miRNAs in several large DNA viruses.
Journal ArticleDOI
The small RNA profile during Drosophila melanogaster development
Alexei A. Aravin,Mariana Lagos-Quintana,Abdullah Yalcin,Mihaela Zavolan,Debora S. Marks,Ben Snyder,Terry Gaasterland,Jutta Meyer,Thomas Tuschl +8 more
TL;DR: The small RNA profile of Drosophila melanogaster is described as a function of development and 178 repeat-associated small interfering RNAs (rasiRNAs) are isolated, suggesting that small RNAs participate in defining chromatin structure.