M
Mariano Dei
Researcher at National Research Council
Publications - 23
Citations - 7952
Mariano Dei is an academic researcher from National Research Council. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 19, co-authored 23 publications receiving 7366 citations. Previous affiliations of Mariano Dei include National Institutes of Health & Technische Universität München.
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Journal ArticleDOI
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.
Angelo Scuteri,Serena Sanna,Wei-Min Chen,Manuela Uda,Giuseppe Albai,James B. Strait,Samer S. Najjar,Ramaiah Nagaraja,Marco Orru,Gianluca Usala,Mariano Dei,Sandra Lai,Andrea Maschio,Fabio Busonero,Antonella Mulas,Georg Ehret,Ashley A Fink,Alan B. Weder,Richard S. Cooper,Pilar Galan,Aravinda Chakravarti,David Schlessinger,Antonio Cao,Edward G. Lakatta,Gonçalo R. Abecasis +24 more
TL;DR: In this paper, a genome-wide association scan was conducted to identify genetic variants associated with obesity-related quantitative traits in the genetically isolated population of Sardinia, and the results showed that common genetic variants in the FTO gene are associated with substantial changes in body weight.
Journal ArticleDOI
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Iris M. Heid,Anne U. Jackson,Joshua C. Randall,Tthomas W. Winkler,Llu Qi,Valgerdur Ssteinthorsdottir,Ggudmar Tthorleifsson,Ccarola Zillikens,Eelizabeth K. Sspeliotes,Eelizabeth K. Sspeliotes,Reedik Mägi,Tsegaselassie Workalemahu,Charles S. White,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Tamara B. Harris,Ssonja I. Berndt,Eerik Ingelsson,Cristen J. Willer,Michael N. Weedon,Jian'an Luan,Ssailaja Vedantam,Ssailaja Vedantam,Tõnu Eesko,Tuomas O. Kilpeläinen,Zoltán Kutalik,Zoltán Kutalik,Sshengxu Li,Keri L. Monda,Anna L. Dixon,Christopher Holmes,Lee M. Kaplan,Liming Liang,J L Min,Miriam F. Moffatt,Cliona Molony,Ggeorge Nicholson,Eeric E. Sschadt,Eeric E. Sschadt,Krina T. Zondervan,Mary F. Feitosa,Teresa Ferreira,Hana Lango Allen,Robert J. Weyant,Eeleanor Wheeler,Andrew R. Wood,Karol Eestrada,Micheal E. Goddard,Micheal E. Goddard,Guillaume Lettre,Massimo Mangino,Dale R. Nyholt,Sshaun Purcell,Sshaun Purcell,Albert Vernon Ssmith,Peter M. Visscher,Jian Yang,Ssteven A. McCcarroll,Ssteven A. McCcarroll,James Nemesh,Benjamin F. Voight,Benjamin F. Voight,Devin Absher,Najaf Amin,Thor Aspelund,Lachlan J. M. Coin,Nicole L. Glazer,Caroline Hayward,Nancy Heard-Ccosta,Jouke-Jan Hottenga,Åsa Johansson,Åsa Johansson,Toby Johnson,Toby Johnson,Toby Johnson,Marika Kaakinen,Karen Kapur,Karen Kapur,Sshamika Ketkar,Joshua W. Knowles,Peter Kraft,Aldi T. Kraja,Claudia Lamina,Micheal F. Leitzmann,Barbara McKknight,Andrew P. Morris,Ken Oong,John R. B. Perry,Marjolein J. Peters,Oozren Polasek,Inga Prokopenko,Nigel W. Rayner,Ssamuli Ripatti,Ssamuli Ripatti,Fernando Rivadeneira,Neil R. Robertson,Serena Sanna,Ulla Sovio,Ida Surakka,Ida Surakka,Alexander Teumer,Sophie H. Van Wingerden,Veronique Vitart,Jing Hua Zhao,Christine Cavalcanti-Proença,Christine Cavalcanti-Proença,Peter S. Chines,Eeva Fisher,Jennifer R. Kulzer,Cécile Lecoeur,Cécile Lecoeur,Narisu Narisu,Camilla H. Sandholt,Laura J. Scott,Kaisa Silander,Kaisa Silander,Klaus Stark,Mari Lliis Tammesoo,Tanya M. Teslovich,Nicholas J. Timpson,Richard M. Watanabe,Ryan P. Welch,Daniel I. Chasman,Mark E. Cooper,John Oolov Jansson,Johannes Kettunen,Johannes Kettunen,Robert Wlawrence,Niina Pellikka,Niina Pellikka,Markus Perola,Markus Perola,Liesbeth Vandenput,Helene Alavere,Peter Almgren,Larry D. Atwood,Amanda J. Bennett,Reiner Biffar,Lori L. Bonnycastle,Stefan R. Bornstein,Thomas A. Buchanan,Harry Campbell,Ian N. M. Day,Mariano Dei,Marcus Dörr,Paul Eelliott,Paul Eelliott,Michael R. Eerdos,Johan G. Eeriksson,Nelson B. Freimer,Mao Fu,Stefan Gaget,Stefan Gaget,Eeco J.C. Geus,Anette P. Gjesing,Harald Grallert,Jürgen Gräßler,Christopher J. Groves,Candace Guiducci,Anna Lliisa Hartikainen,Neelam Hassanali,Aki S. Havulinna,Karl-Heinz Herzig,Karl-Heinz Herzig,Andrew A. Hicks,Jennie Hui,Jennie Hui,Wilmar Igl,Pekka Jousilahti,Antti Jula,Eeero Kajantie,Leena Kinnunen,Ivana Kolcic,Seppo Koskinen,Peter Kovacs,Heyo K. Kroemer,Vjekoslav Krzelj,Johanna Kuusisto,Kirsti Kvaløy,Jaana Laitinen,Oolivier Lantieri,Mark Lathrop,Marja Llokki Lokki,Robert Luben,Barbara Ludwig,Wendy L. McArdle,Anne McCcarthy,Mario A. Morken,Mari Nelis,Mari Nelis,Matt Neville,Guillaume Paré,Alex N. Parker,John F. Peden,Irene Pichler,Kirsi H. Pietiläinen,Carl G. P. Platou,Anneli Pouta,Anneli Pouta,Martin Ridderstråle,Nilesh J. Samani,Nilesh J. Samani,Jouko Saramies,Juha Sinisalo,Jan Smit,Rona J. Strawbridge,Heather M. Stringham,Amy J. Swift,Maris Teder-Llaving,Maris Teder-Llaving,Brian Thomson,Gianluca Usala,Joyce B.J. Van Mmeurs,Gert-Jan B. van Ommen,Vincent Vatin,Vincent Vatin,Claudia B. Volpato,Henri Wallaschofski,Bragi Walters,Eelisabeth Widen,Sarah H. Wild,Gonneke Willemsen,Deniel R. Witte,Lina Zgaga,Paavo Zitting,John Beilby,John Beilby,Alan L. James,Alan L. James,Mika Kähönen,Terho Lehtimäki,Markku S. Nieminen,Claes Ohlsson,Lyle J. Palmer,Lyle J. Palmer,Olli T. Raitakari,Paul M. Ridker,Micheal Stumvoll,Anke Tönjes,Jorma Viikari,Beverley Balkau,Yoav Ben-Shlomo,Richard N. Bergman,Heiner Boeing,George Ddavey Smith,Shah Eebrahim,Philippe Froguel,Philippe Froguel,Philippe Froguel,Torben Hansen,Torben Hansen,Christian Hengstenberg,Kristian Hveem,Bo Isomaa,Torben Jørgensen,Fredrik Karpe,Kay Ttee Khaw,Markku Laakso,Debbie A Lawlor,Michel Marre,Michel Marre,Thomas Meitinger,Andres Metspalu,Andres Metspalu,Kristian Midthjell,Oluf Pedersen,Oluf Pedersen,Oluf Pedersen,Veikko Salomaa,Peter Schwarz,Tiinamaija Tuomi,Jaakko Tuomilehto,Jaakko Tuomilehto,Timo T. Valle,Nicholas J. Wareham,Alice M. Arnold,Jacques S. Beckmann,Sven Bergmann,Sven Bergmann,Eeric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Francis S. Collins,Gudny Eeiriksdottir,Vilmundur Gudnason,Ulf Gyllensten,Anders Hamsten,Andrew T. Hattersley,Albert Hofman,Frank B. Hu,Thomas Illig,Carlos Iribarren,Carlos Iribarren,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,W. H. Linda Kao,Jaakko Kaprio,Jaakko Kaprio,Lenore J. Launer,Patricia B. Munroe,Ben A. Oostra,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Peter P. Pramstaller,Bruce M. Psaty,Bruce M. Psaty,Thomas Quertermous,Aila Rissanen,Igor Rudan,Igor Rudan,Alan R. Shuldiner,Alan R. Shuldiner,Nicole Soranzo,Nicole Soranzo,Tim D. Spector,Ann Cchristine Syvanen,Manuela Uda,André G. Uitterlinden,Henry Völzke,Peter Vollenweider,James F. Wilson,Jacqueline C. M. Witteman,Alan F. Wright,Gonçalo R. Abecasis,M Boehnke,Ingrid B. Borecki,Panos Deloukas,Timothy M. Frayling,Leif Groop,Talin Haritunians,David J. Hunter,Robert C. Kaplan,Kari E. North,Jeffrey R. O'Cconnell,Leena Peltonen,David Schlessinger,David P. Strachan,Joel N. Hirschhorn,Joel N. Hirschhorn,Themistocles L. Assimes,H. Eerich Wichmann,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Cornelia Van Dduijn,Kari Stefansson,Kari Stefansson,Adrienne Cupples,Ruth J. F. Loos,Inês Barroso,Inês Barroso,Mark I. McCcarthy,Caroline S. Fox,Karen L. Mohlke,Cecilia M. Lindgren +355 more
TL;DR: A meta-analysis of genome-wide association studies for WHR adjusted for body mass index provides evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Iris M. Heid,Anne U. Jackson,Joshua C. Randall,Thomas W. Winkler,Lu Qi,Valgerdur Steinthorsdottir,Gudmar Thorleifsson,M. Carola Zillikens,Elizabeth K. Speliotes,Reedik Maegi,Tsegaselassie Workalemahu,Charles C. White,Nabila Bouatia-Naji,Tamara B. Harris,Sonja I. Berndt,Erik Ingelsson,Cristen J. Willer,Michael N. Weedon,Jian'an Luan,Sailaja Vedantam,Tõnu Esko,Tuomas O. Kilpelaeinen,Zoltán Kutalik,Shengxu Li,Keri L. Monda,Anna L. Dixon,Christopher Holmes,Lee M. Kaplan,Liming Liang,Josine L. Min,Miriam F. Moffatt,Cliona Molony,George Nicholson,Eric E. Schadt,Krina T. Zondervan,Mary F. Feitosa,Teresa Ferreira,Hana Lango Allen,Robert J. Weyant,Eleanor Wheeler,Andrew R. Wood,Karol Estrada,Michael E. Goddard,Guillaume Lettre,Massimo Mangino,Dale R. Nyholt,Shaun Purcell,Albert V. Smith,Peter M. Visscher,Jian Yang,Steven A. McCarroll,James Nemesh,Benjamin F. Voight,Devin Absher,Najaf Amin,Thor Aspelund,Lachlan J. M. Coin,Nicole L. Glazer,Caroline Hayward,Nancy L. Heard-Costa,Jouke-Jan Hottenga,Åsa Johansson,Toby Johnson,Marika Kaakinen,Karen Kapur,Shamika Ketkar,Joshua W. Knowles,Peter Kraft,Aldi T. Kraja,Claudia Lamina,Michael F. Leitzmann,Barbara McKnight,Andrew P. Morris,Ken K. Ong,John R. B. Perry,Marjolein J. Peters,Ozren Polasek,Inga Prokopenko,Nigel W. Rayner,Samuli Ripatti,Fernando Rivadeneira,Neil R. Robertson,Serena Sanna,Ulla Sovio,Ida Surakka,Alexander Teumer,Sophie van Wingerden,Veronique Vitart,Jing Hua Zhao,Christine Cavalcanti-Proença,Peter S. Chines,Eva Fisher,Jennifer R. Kulzer,Cécile Lecoeur,Narisu Narisu,Camilla H. Sandholt,Laura J. Scott,Kaisa Silander,Klaus Stark,Mari-Liis Tammesoo,Tanya M. Teslovich,Nicholas J. Timpson,Richard M. Watanabe,Ryan P. Welch,Daniel I. Chasman,Mark E. Cooper,John-Olov Jansson,Johannes Kettunen,Robert Lawrence,Niina Pellikka,Markus Perola,Liesbeth Vandenput,Helene Alavere,Peter Almgren,Larry D. Atwood,Amanda J. Bennett,Reiner Biffar,Lori L. Bonnycastle,Stefan R. Bornstein,Thomas A. Buchanan,Harry Campbell,Ian N.M. Day,Mariano Dei,Marcus Doerr,Paul Elliott,Michael R. Erdos,Johan G. Eriksson,Nelson B. Freimer,Mao Fu,Stefan Gaget,Eco J. C. de Geus,Anette P. Gjesing,Harald Grallert,Juergen Graessler,Christopher J. Groves,Candace Guiducci,Anna-Liisa Hartikainen,Neelam Hassanali,Aki S. Havulinna,Karl-Heinz Herzig,Andrew A. Hicks,Jennie Hui,Wilmar Igl,Pekka Jousilahti,Antti Jula,Eero Kajantie,Leena Kinnunen,Ivana Kolcic,Seppo Koskinen,Peter Kovacs,Heyo K. Kroemer,Vjekoslav Krzelj,Johanna Kuusisto,Kirsti Kvaløy,Jaana Laitinen,Olivier Lantieri,G. Mark Lathrop,Marja-Liisa Lokki,Robert Luben,Barbara Ludwig,Wendy L. McArdle,Anne Marie McCarthy,Mario A. Morken,Mari Nelis,Matt Neville,Guillaume Paré,Alex N. Parker,John F. Peden,Irene Pichler,Kirsi H. Pietiläinen,Carl G. P. Platou,Anneli Pouta,Martin Ridderstråle,Nilesh J. Samani,Jouko Saramies,Juha Sinisalo,Jan Smit,Rona J. Strawbridge,Heather M. Stringham,Amy J. Swift,Maris Teder-Laving,Brian Thomson,Gianluca Usala,Joyce B. J. van Meurs,Gert-Jan B. van Ommen,Vincent Vatin,Claudia B. Volpato,Henri Wallaschofski,G. Bragi Walters,Elisabeth Widen,Sarah H. Wild,Gonneke Willemsen,Daniel R. Witte,Lina Zgaga,Paavo Zitting,John Beilby,Alan L. James,Mika Kähönen,Terho Lehtimäki,Markku S. Nieminen,Claes Ohlsson,Lyle J. Palmer,Olli T. Raitakari,Paul M. Ridker,Michael Stumvoll,Anke Toenjes,Jorma Viikari,Beverley Balkau,Yoav Ben-Shlomo,Richard N. Bergman,Heiner Boeing,George Davey Smith,Shah Ebrahim,Philippe Froguel,Torben Hansen,Christian Hengstenberg,Kristian Hveem,Bo Isomaa,Torben Jørgensen,Fredrik Karpe,Kay-Tee Khaw,Markku Laakso,Debbie A Lawlor,Michel Marre,Thomas Meitinger,Andres Metspalu,Kristian Midthjell,Oluf Pedersen,Veikko Salomaa,Peter Schwarz,Tiinamaija Tuomi,Jaakko Tuomilehto,Timo T. Valle,Nicholas J. Wareham,Alice M. Arnold,Jacques S. Beckmann,Sven Bergmann,Eric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Francis S. Collins,Gudny Eiriksdottir,Vilmundur Gudnason,Ulf Gyllensten,Anders Hamsten,Andrew T. Hattersley,Albert Hofman,Frank B. Hu,Thomas Illig,Carlos Iribarren,Marjo-Riitta Järvelin,W. H. Linda Kao,Jaakko Kaprio,Lenore J. Launer,Patricia B. Munroe,Ben A. Oostra,Brenda W.J.H. Penninx,Peter P. Pramstaller,Bruce M. Psaty,Thomas Quertermous,Aila Rissanen,Igor Rudan,Alan R. Shuldiner,Nicole Soranzo,Tim D. Spector,Ann-Christine Syvänen,Manuela Uda,André G. Uitterlinden,Henry Voelzke,Peter Vollenweider,James F. Wilson,Jacqueline C. M. Witteman,Alan F. Wright,Gonçalo R. Abecasis,Michael Boehnke,Ingrid B. Borecki,Panos Deloukas,Timothy M. Frayling,Leif Groop,Talin Haritunians,David J. Hunter,Robert C. Kaplan,Kari E. North,Jeffrey R. O'Connell,Leena Peltonen,David Schlessinger,David P. Strachan,Joel N. Hirschhorn,Themistocles L. Assimes,H-Erich Wichmann,Unnur Thorsteinsdottir,Cornelia M. van Duijn,Kari Stefansson,L. Adrienne Cupples,Ruth J. F. Loos,Inês Barroso,Mark I. McCarthy,Caroline S. Fox,Karen L. Mohlke,Cecilia M. Lindgren +299 more
Journal ArticleDOI
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia
Manuela Uda,Renzo Galanello,Serena Sanna,Guillaume Lettre,Guillaume Lettre,Vijay G. Sankaran,Wei-Min Chen,Gianluca Usala,Fabio Busonero,Andrea Maschio,Giuseppe Albai,Maria Grazia Piras,Natascia Sestu,Sandra Lai,Mariano Dei,Antonella Mulas,Laura Crisponi,Silvia Naitza,Isadora Asunis,Manila Deiana,Ramaiah Nagaraja,Lucia Perseu,Stefania Satta,Maria Dolores Cipollina,Carla Sollaino,Paolo Moi,Joel N. Hirschhorn,Joel N. Hirschhorn,Stuart H. Orkin,G. Abecasis,David Schlessinger,Antonio Cao +31 more
TL;DR: It is indicated that BCL11A variants, by modulating HbF levels, act as an important ameliorating factor of the β-thalassemia phenotype, and it is likely they could helpAmeliorate other hemoglobin disorders.
Journal ArticleDOI
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Sonja I. Berndt,Stefan Gustafsson,Stefan Gustafsson,Reedik Mägi,Reedik Mägi,Andrea Ganna,Eleanor Wheeler,Mary F. Feitosa,Anne E. Justice,Keri L. Monda,Keri L. Monda,Damien C. Croteau-Chonka,Felix R. Day,Tõnu Esko,Tove Fall,Teresa Ferreira,Davide Gentilini,Anne U. Jackson,Jian'an Luan,Joshua C. Randall,Joshua C. Randall,Sailaja Vedantam,Sailaja Vedantam,Sailaja Vedantam,Cristen J. Willer,Thomas W. Winkler,Andrew R. Wood,Tsegaselassie Workalemahu,Tsegaselassie Workalemahu,Yi-Juan Hu,Sang Hong Lee,Liming Liang,Danyu Lin,Josine L. Min,Benjamin M. Neale,Gudmar Thorleifsson,Jian Yang,Jian Yang,Eva Albrecht,Najaf Amin,Jennifer L. Bragg-Gresham,Gemma Cadby,Gemma Cadby,Martin den Heijer,Niina Eklund,Krista Fischer,Anuj Goel,Jouke-Jan Hottenga,Jennifer E. Huffman,Ivonne Jarick,Åsa Johansson,Åsa Johansson,Toby Johnson,Stavroula Kanoni,Marcus E. Kleber,Inke R. König,Kati Kristiansson,Zoltán Kutalik,Zoltán Kutalik,Claudia Lamina,Cécile Lecoeur,Cécile Lecoeur,Guo Li,Massimo Mangino,Wendy L. McArdle,Carolina Medina-Gomez,Martina Müller-Nurasyid,Julius S. Ngwa,Ilja M. Nolte,Lavinia Paternoster,Sonali Pechlivanis,Markus Perola,Markus Perola,Markus Perola,Marjolein J. Peters,Michael Preuss,Lynda M. Rose,Jianxin Shi,Dmitry Shungin,Dmitry Shungin,Albert V. Smith,Rona J. Strawbridge,Ida Surakka,Ida Surakka,Alexander Teumer,Mieke D. Trip,Jonathan Tyrer,Jana V. van Vliet-Ostaptchouk,Liesbeth Vandenput,Lindsay L. Waite,Jing Hua Zhao,Devin Absher,Folkert W. Asselbergs,Mustafa Atalay,Antony P. Attwood,Anthony J. Balmforth,Hanneke Basart,John Beilby,Lori L. Bonnycastle,Paolo Brambilla,Marcel Bruinenberg,Harry Campbell,Daniel I. Chasman,Daniel I. Chasman,Peter S. Chines,Francis S. Collins,John M. C. Connell,John M. C. Connell,William O.C.M. Cookson,Ulf de Faire,Femmie de Vegt,Mariano Dei,Maria Dimitriou,Sarah Edkins,Karol Estrada,David M. Evans,Martin Farrall,Marco M Ferrario,Jean Ferrières,Lude Franke,Francesca Frau,Pablo V. Gejman,Pablo V. Gejman,Harald Grallert,Henrik Grönberg,Vilmundur Gudnason,Alistair S. Hall,Per Hall,Anna-Liisa Hartikainen,Caroline Hayward,Nancy L. Heard-Costa,Andrew C. Heath,Johannes Hebebrand,Georg Homuth,Frank B. Hu,Sarah E. Hunt,Elina Hyppönen,Carlos Iribarren,Kevin B. Jacobs,Kevin B. Jacobs,John-Olov Jansson,Antti Jula,Mika Kähönen,Sekar Kathiresan,Frank Kee,Kay-Tee Khaw,Mika Kivimäki,Wolfgang Koenig,Aldi T. Kraja,Meena Kumari,Kari Kuulasmaa,Johanna Kuusisto,Jaana Laitinen,Timo A. Lakka,Claudia Langenberg,Claudia Langenberg,Lenore J. Launer,Lars Lind,Jaana Lindström,Jianjun Liu,Antonio Liuzzi,Marja-Liisa Lokki,Mattias Lorentzon,Pamela A. F. Madden,Patrik K. E. Magnusson,Paolo Manunta,Diana Marek,Diana Marek,Winfried März,Winfried März,Irene Mateo Leach,Barbara McKnight,Sarah E. Medland,Evelin Mihailov,Lili Milani,Grant W. Montgomery,Vincent Mooser,Thomas W. Mühleisen,Patricia B. Munroe,Arthur W. Musk,Arthur W. Musk,Narisu Narisu,Gerjan Navis,George Nicholson,Ellen A. Nohr,Ken K. Ong,Ben A. Oostra,Ben A. Oostra,Colin N. A. Palmer,Aarno Palotie,Aarno Palotie,John F. Peden,Nancy L. Pedersen,Annette Peters,Ozren Polasek,Anneli Pouta,Anneli Pouta,Peter P. Pramstaller,Inga Prokopenko,Inga Prokopenko,Carolin Pütter,Aparna Radhakrishnan,Aparna Radhakrishnan,Aparna Radhakrishnan,Olli T. Raitakari,Olli T. Raitakari,Augusto Rendon,Fernando Rivadeneira,Igor Rudan,Timo Saaristo,Jennifer G. Sambrook,Jennifer G. Sambrook,Alan R. Sanders,Alan R. Sanders,Serena Sanna,Jouko Saramies,Sabine Schipf,Stefan Schreiber,Heribert Schunkert,So-Youn Shin,Stefano Signorini,Juha Sinisalo,Boris Skrobek,Boris Skrobek,Nicole Soranzo,Nicole Soranzo,Alena Stančáková,Klaus Stark,Jonathan Stephens,Jonathan Stephens,Kathleen Stirrups,Ronald P. Stolk,Michael Stumvoll,Amy J. Swift,Eirini V. Theodoraki,Barbara Thorand,David-Alexandre Trégouët,Elena Tremoli,Melanie M. van der Klauw,Joyce B. J. van Meurs,Sita H. Vermeulen,Jorma Viikari,Jarmo Virtamo,Veronique Vitart,Gérard Waeber,Zhaoming Wang,Zhaoming Wang,Elisabeth Widen,Sarah H. Wild,Gonneke Willemsen,Bernhard R. Winkelmann,Jacqueline C.M. Witteman,Bruce H. R. Wolffenbuttel,Andrew Wong,Alan F. Wright,M. Carola Zillikens,Philippe Amouyel,Bernhard O. Boehm,Eric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Stephen J. Chanock,L. Adrienne Cupples,Daniele Cusi,George Dedoussis,Jeanette Erdmann,Jeanette Erdmann,Johan G. Eriksson,Johan G. Eriksson,Johan G. Eriksson,Paul W. Franks,Paul W. Franks,Paul W. Franks,Philippe Froguel,Philippe Froguel,Philippe Froguel,Christian Gieger,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Christian Hengstenberg,Andrew A. Hicks,Aroon D. Hingorani,Anke Hinney,Albert Hofman,Kees Hovingh,Kristian Hveem,Thomas Illig,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Sirkka Keinänen-Kiukaanniemi,Sirkka Keinänen-Kiukaanniemi,Lambertus A. Kiemeney,Diana Kuh,Markku Laakso,Terho Lehtimäki,Douglas F. Levinson,Nicholas G. Martin,Andres Metspalu,Andrew D. Morris,Markku S. Nieminen,Inger Njølstad,Claes Ohlsson,Albertine J. Oldehinkel,Willem H. Ouwehand,Lyle J. Palmer,Brenda W.J.H. Penninx,Chris Power,Michael A. Province,Bruce M. Psaty,Lu Qi,Lu Qi,Rainer Rauramaa,Paul M. Ridker,Paul M. Ridker,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Veikko Salomaa,Nilesh J. Samani,Nilesh J. Samani,Harold Snieder,Thorkild I. A. Sørensen,Tim D. Spector,Kari Stefansson,Kari Stefansson,Anke Tönjes,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,André G. Uitterlinden,Matti Uusitupa,Pim van der Harst,Peter Vollenweider,Henri Wallaschofski,Nicholas J. Wareham,Hugh Watkins,H-Erich Wichmann,James F. Wilson,Gonçalo R. Abecasis,Themistocles L. Assimes,Inês Barroso,Inês Barroso,Michael Boehnke,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Timothy M. Frayling,Leif Groop,Talin Haritunian,Iris M. Heid,David J. Hunter,David J. Hunter,Robert C. Kaplan,Fredrik Karpe,Fredrik Karpe,Miriam F. Moffatt,Karen L. Mohlke,Jeffrey R. O'Connell,Yudi Pawitan,Eric E. Schadt,David Schlessinger,Valgerdur Steinthorsdottir,David P. Strachan,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Cornelia M. van Duijn,Cornelia M. van Duijn,Peter M. Visscher,Anna Maria Di Blasio,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Cecilia M. Lindgren,Andrew P. Morris,David Meyre,David Meyre,David Meyre,André Scherag,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Elizabeth K. Speliotes,Kari E. North,Ruth J. F. Loos,Erik Ingelsson +385 more
TL;DR: A genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry finds a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.