Author
Marie Laronze
Other affiliations: Centre national de la recherche scientifique
Bio: Marie Laronze is an academic researcher from University of Reims Champagne-Ardenne. The author has contributed to research in topics: Indole test & Condensation. The author has an hindex of 7, co-authored 12 publications receiving 236 citations. Previous affiliations of Marie Laronze include Centre national de la recherche scientifique.
Papers
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TL;DR: In this paper, pyrrolidino-fused (aza) carbazoles were prepared and screened towards a few cancer-related targets, including 28a and 28a derivatives.
79 citations
TL;DR: In this paper, a short and general synthesis for the preparation of various conformationally constrained β-substituted tryptophans has been elaborated starting from indole, aldehydes and Meldrum's acid by using trimolecular condensation and Curtius rearrangement mediated functional group transformations followed by deprotections, as key-steps.
45 citations
TL;DR: In this paper, electron-donating substituted 3-cyanomethyl-2-vinylindoles were found to rearrange via thermal shift into the corresponding indole-2,3-quinodimethanes which were trapped by dienophiles to afford tetrahydrocarbazoles.
33 citations
TL;DR: An access to functionalised tetrahydrocarbazoles by a multicomponent reaction including 2-substituted indoles, aromatic aldehydes and Meldrum's acid is described in this article.
29 citations
TL;DR: In this paper, the relative stereochemistry of the spiro derivatives was determined by comparison of NOESY data and calculated conformational analyses, based on a three-step procedure characterized by acyl azide formation, Curtius rearrangement, and subsequent thermal spiro cyclization.
22 citations
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TL;DR: Asymmetric multicomponent reactions involve the preparation of chiral compounds by the reaction of three or more reagents added simultaneously and has some advantages over classic divergent reaction strategies, such as lower costs, time, and energy, as well as environmentally friendlier aspects.
Abstract: Asymmetric multicomponent reactions involve the preparation of chiral compounds by the reaction of three or more reagents added simultaneously. This kind of addition and reaction has some advantages over classic divergent reaction strategies, such as lower costs, time, and energy, as well as environmentally friendlier aspects. All these advantages, together with the high level of stereoselectivity attained in some of these reactions, will force chemists in industry as in academia to adopt this new strategy of synthesis, or at least to consider it as a viable option. The positive aspects as well as the drawbacks of this strategy are discussed in this Review.
1,479 citations
663 citations
TL;DR: In this article, an overview of the potential of 1,3-dicarbonyl derivatives for the selective construction of highly functionalised small organic molecules of high synthetic and biological value is presented.
507 citations
TL;DR: Novel histone deacetylase inhibitors are provided, which are particularly useful in treating cutaneous T-cell lymphoma, neurofibromatosis, psoriasis, hair loss, skin pigmentation, and dermatitis, for exmaple.
Abstract: Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group or a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, and genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy.
437 citations
TL;DR: In this article, the Synthese von chiralen Verbindungen aus drei oder mehr gleichzeitig zusammengegebenen Reaktionspartnern is discussed.
Abstract: Unter der asymmetrischen Mehrkomponenten-Reaktion versteht man die Synthese von chiralen Verbindungen aus drei oder mehr gleichzeitig zusammengegebenen Reaktionspartnern. Diese Art der Zugabe und Umsetzung hat gegenuber klassischen divergenten Strategien eine Reihe von Vorteilen, darunter ein geringerer Aufwand an Kosten, Zeit und Energie sowie eine bessere Umweltvertraglichkeit. Dies und die hohe Stereoselektivitat mancher Reaktionen werden diese neue Synthesestrategie fur die chemische Industrie und fur Hochschulen zunehmend wichtig machen. In diesem Aufsatz werden die Vorzuge, aber auch die Probleme asymmetrischer Mehrkomponenten-Reaktionen diskutiert.
301 citations