Mariella Dono

TL;DR: It is demonstrated thatmiR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate BCL2 at a posttranscriptional level and are natural antisense B cl2 interactors that could be used for therapy of Bcl1-overexpressing tumors.

TL;DR: A recently developed methodology for miRNA gene expression profiling based on the development of a microchip containing oligonucleotides corresponding to 245 miRNAs from human and mouse genomes is described.

TL;DR: The data suggest that in MS there is a compartmentalized clonal expansion and no intraclonal diversification could be observed even using VH3 gene-specific PCR methodologies.

TL;DR: The findings suggest that the B lymphocytes that gave rise to five IgG(+) B-CLL cells were selected for this unique BCR structure, and that these BCRs could bind the same antigenic epitope.

TL;DR: The data indicate that CD38 expression identified a particular subset of B-CLL cells with defined functional properties, including the propensity to undergo apoptosis, which is unlike that observed in normal circulating B cells.