M
Marina A. Pak
Researcher at Skolkovo Institute of Science and Technology
Publications - 2
Citations - 64
Marina A. Pak is an academic researcher from Skolkovo Institute of Science and Technology. The author has contributed to research in topics: Homology modeling & Structural biology. The author has an hindex of 2, co-authored 2 publications receiving 6 citations.
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Using AlphaFold to predict the impact of single mutations on protein stability and function
Marina A. Pak,Karina A. Markhieva,Mariia S. Novikova,Dmitry S. Petrov,Ilya S. Vorobyev,Ekaterina S. Maksimova,Fyodor A. Kondrashov,Dmitry N. Ivankov +7 more
TL;DR: In this paper, the ability of AlphaFold to predict the impact of single mutations on protein stability and function has been examined, and it was shown that there is no correlation between alphaFold output metrics and change of protein stability or fluorescence.
Posted ContentDOI
Best templates outperform homology models in predicting the impact of mutations on protein stability
Marina A. Pak,Dmitry N. Ivankov +1 more
TL;DR: In this article, the authors used the most popular and accurate publicly available tools: FoldX for stability change prediction and I-Tasser for homology modeling, with best templates performing 1.5 times better than homology models.