Marina S. Konkova

TL;DR: The oxidized DNA is a stress signal released in response to oxidative stress in the cultured cells and, possibly, in the human body; in particular, it might contribute to systemic abscopal effects of localized irradiation treatments.

TL;DR: It is believed that ecDNA of irradiated apoptotic lymphocytes is a significant factor of stress-signalling and may be followed by relatively long-lasting in the cellular population oxidative stress contributing to the development of an adaptive response.

TL;DR: The presence of the radiation-induced apoptosis in the bystander effect being studied suggests a possibility for radiation-modified ecDNA fragments to be released into the culture medium, whereas inhibition of TLR9 suggests the binding these ligands to the recipient cells.

TL;DR: It is shown that oxidized extracellular DNA stimulates the survival of MCF-7 tumor cells, and survival of cells with an unstable genome may substantially augment progression of malignancy.

TL;DR: The bystander lymphocytes were found to demonstrate both transposition of the loci of homologous chromosomes and activation of the chromosomal NFRs, whereas after inoculation of the DNA fragments of the unirradiated cells, neither of the above effects was observed.