Marine Movsisyan

Bio: Marine Movsisyan is an academic researcher from Ghent University. The author has contributed to research in topics: Carboxylic acid & Flow chemistry. The author has an hindex of 5, co-authored 13 publications receiving 451 citations.

Taming hazardous chemistry by continuous flow technology

Abstract: Over the last two decades, flow technologies have become increasingly popular in the field of organic chemistry, offering solutions for engineering and/or chemical problems. Flow reactors enhance the mass and heat transfer, resulting in rapid reaction mixing, and enable a precise control over the reaction parameters, increasing the overall process selectivity, efficiency and safety. These features allow chemists to tackle unexploited challenges in their work, with the ultimate objective making chemistry more accessible for laboratory and industrial applications, avoiding the need to store and handle toxic, reactive and explosive reagents. This review covers some of the latest and most relevant developments in the field of continuous flow chemistry with the focus on hazardous reactions.

Safe, Selective, and High-Yielding Synthesis of Acryloyl Chloride in a Continuous-Flow System.

Abstract: Acid chlorides are an important class of compounds and their high reactivity and instability has prompted us to develop a straightforward procedure for their synthesis with on-demand and on-site synthesis possibilities. The focus of this report is acryloyl chloride, mainly important for the acrylate and polymer industry. A continuous-flow methodology was developed for the fast and selective synthesis of the otherwise highly unstable acryloyl chloride. Three routes were investigated in a microreactor setup and all three can potentially be used for its production. The methodology was further expanded to the synthesis of other unstable acid chlorides by both the thionyl chloride and the oxalyl chloride mediated processes. The most sustainable method was the oxalyl chloride mediated procedure under solvent-free conditions, in which near-equimolar amounts of carboxylic acid and oxalyl chloride were used in the presence of catalytic amounts of DMF at room temperature. Within 1 to 3 min, nearly full conversions into the acid chlorides were achieved.

Taming Hazardous Chemistry by Continuous Flow Technology

Abstract: Over the last two decades, flow technologies have become increasingly popular in the field of organic chemistry, offering solutions for engineering and/or chemical problems. Flow reactors enhance the mass and heat transfer, resulting in rapid reaction mixing, and enable a precise control over the reaction parameters, increasing the overall process selectivity, efficiency and safety. These features allow chemists to tackle unexploited challenges in their work, with the ultimate objective making chemistry more accessible for laboratory and industrial applications, avoiding the need to store and handle toxic, reactive and explosive reagents. This review covers some of the latest and most relevant developments in the field of continuous flow chemistry with the focus on hazardous reactions.

The Hitchhiker's Guide to Flow Chemistry

Abstract: Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous stream rather than in a flask Flow equipment provides chemists with unique control over reaction parameters enhancing reactivity or in some cases enabling new reactions This relatively young technology has received a remarkable amount of attention in the past decade with many reports on what can be done in flow Until recently, however, the question, “Should we do this in flow?” has merely been an afterthought This review introduces readers to the basic principles and fundamentals of flow chemistry and critically discusses recent flow chemistry accounts

Flow chemistry—Microreaction technology comes of age

Abstract: Over the past two decades, microreaction technology has matured from early devices and concepts to encompass a wide range of commercial equipment and applications. This evolution has been aided by the confluence of microreactor development and adoption of continuous flow technology in organic chemistry. This Perspective summarizes the current state-of-the art with focus on enabling technologies for reaction and separation equipment. Automation and optimization are highlighted as promising applications of microreactor technology. The move towards continuous processing in pharmaceutical manufacturing underscores increasing industrial interest in the technology. As an example, end-to-end fabrication of pharmaceuticals in a compact reconfigurable system illustrates the development of on-demand manufacturing units based on microreactors. The final section provides an outlook for the technology, including implementation challenges and integration with computational tools. AIChE J, 2017 © 2016 American Institute of Chemical Engineers AIChE J, 63: 858–869, 2017