M
Mario Grifantini
Researcher at University of Camerino
Publications - 126
Citations - 2522
Mario Grifantini is an academic researcher from University of Camerino. The author has contributed to research in topics: Adenosine & Adenosine receptor. The author has an hindex of 28, co-authored 126 publications receiving 2402 citations. Previous affiliations of Mario Grifantini include Indiana University & University of Naples Federico II.
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Journal ArticleDOI
2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors.
Martin J. Lohse,Karl-Norbert Klotz,Ulrich Schwabe,Gloria Cristalli,Sauro Vittori,Mario Grifantini +5 more
TL;DR: CCPA is an agonist at A1 adenosine receptors with a 4-foldHigher selectivity and 2-fold higher affinity than CPA, and a considerably higher selectivity than the standard A1 receptor agonist R-N6-phenylisopropyladenosine (R-PIA).
Journal ArticleDOI
2-Chloro-N6-[3H]cyclopentyladenosine ([3H]CCPA)--a high affinity agonist radioligand for A1 adenosine receptors.
Karl-Norbert Klotz,Martin J. Lohse,Ulrich Schwabe,Gloria Cristalli,Sauro Vittori,Mario Grifantini +5 more
TL;DR: Based on the subnanomolar affinity and the high selectivity for A1 receptors [3H]CCPA proved to be a useful agonist radioligand for characterization of A1 adenosine receptors also in tissues with very low receptor density.
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Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
Palmarisa Franchetti,Loredana Cappellacci,Mario Grifantini,A. Barzi,Giuseppe Nocentini,Hongyoan Yang,Ayrn O'Connor,Hiremagalur N. Jayaram,Christopher J. Carrell,Barry M. Goldstein +9 more
TL;DR: The results obtained support the hypothesis that the presence of S in the heterocycle in position 2 with respect to the glycosidic bond is essential for the cytotoxicity and IMP dehydrogenase activity of tiazofurin, while the N atom is not.
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Decomposition pathways and in vitro HIV inhibitory effects of isoddA pronucleotides: toward a rational approach for intracellular delivery of nucleoside 5'-monophosphates.
G. Valette,A. Pompon,J.-L. Girardet,Loredana Cappellacci,Palmarisa Franchetti,Mario Grifantini,P. La Colla,A. G. Loi,C. Perigaud,G. Gosselin,J.-L. Imbach +10 more
TL;DR: The results highlight that both types of compounds act as pronucleotides, i.e. they exert their antiviral effect via intracellular delivery of the 5'-mononucleotide of isoddA.
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Nucleoside and Non‐nucleoside IMP Dehydrogenase Inhibitors as Antitumor and Antiviral Agents
TL;DR: In this article, two isoforms of human IMPDH, designed type I and type II, have been identified and sequenced, and two types of inhibitors have been discovered so far: nucleoside inhibitors, such as ribavirin and tiazofurin, and non-nucleoside such as mycophenolic acid.